öλÔÓéÀֵǼÈë¿ÚÏÂÔØ

ÍõѧÇå ²©Ê¿£¬¸±½ÌÊÚ£¬Ë¶Ê¿Ñо¿Éúµ¼Ê¦

µç»°£º010-82801584,

µç×ÓÐÅÏ䣺wangxq@bjmu.edu.cn

1989.9-1993.7 ±±¾©Ò½¿Æ´óѧҩѧöλÔÓéÀֵǼÈë¿ÚÏÂÔØѧϰ£¬»ñѧʿѧλ¡£2001.9-2003.7ÄêÓÚ±±¾©´óѧҩ¼ÁѧöλÔÓéÀֵǼÈë¿ÚÏÂÔØÔÚְѧϰ£¬»ñ˶ʿѧλ¡£2005.9-2008.7ÄêÓÚÖйú¿ÆѧԺÉúÎïÎïÀíÑо¿ËùÔÚְѧϰ£¬»ñ²©Ê¿Ñ§Î»¡£2011ÄêÓڰµØÀûÒò˹²¼Â³¿Ë´óѧ½øÐÞѧϰÈý¸öÔ¡£1993.8ÁôУºó½øÈë±±¾©Ò½¿Æ´óѧҩѧԺҩ¼Á½ÌÑÐÊÒ´ÓʽÌѧºÍ¿ÆÑй¤×÷£¬Ö÷Òª³Ðµ£±¾¿ÆÉú¡¢Ñо¿ÉúµÄÒ©¼Áѧ¡¢ÉúÎïÒ©¼ÁѧÓëÒ©ÎﶯÁ¦Ñ§µÄÀíÂۿγÌÓëʵÑé¿Î³ÌµÄ½Ìѧ¹¤×÷¡£1998ÄêƸΪ½²Ê¦£¬2009ÄêƸΪ¸±½ÌÊÚ¡£²ÎÓë¶àÏî¹ú¼Ò¿ÎÌâºÍÐÂÒ©ÖƼÁ¿ª·¢¹¤×÷£¬ÈçNSFÖصã×ÊÖúÏîÄ¿¡°»ùÓÚ·Ö×Ó°ÐÏò¸øÒ©µÄÖ×ÁöÁªºÏÖÎÁÆ¡±£¨ÔÚÑУ©¡¢973¼Æ»®×ÊÖúÏîÄ¿¡°ÄÉÃ×¼¼Êõ¸ÄÉÆÄÑÈÜÐÔÒ©Î﹦ЧµÄÓ¦Óûù´¡Ñо¿¡± £¨ÔÚÑУ©¡¢¿Æ¼¼²¿¡°ÖØ´óÐÂÒ©´´ÖÆ¡±ÐÂÖƼÁÓëÐÂÊÍҩϵͳ¼¼Êõƽ̨½¨ÉèÏîÄ¿£¨ÔÚÑУ©¡¢863¼Æ»®×ÊÖúÏîÄ¿¡°»·æßËØAÄÉÃ×Á£¿Ú·þ¼ÁÐ͵ÄÑо¿¡±£¨ÒѽáÌ⣩¡¢NSFÖصã×ÊÖúÏîÄ¿¡°ÔØÌå¸øҩϵͳµÄ·Ö×ÓÒ©¼Áѧ¡± £¨ÒѽáÌ⣩¡¢¡°òÇò¾ÏËÁ¬µ°°×øÔÚÒÒÐ͸ÎÑ×ÖÎÁÆÖеĻù´¡Ñо¿¡±¡¢Ò»ÀàÐÂÒ©¡°RS-27 ÊäÒº¼ÁµÄÑÐÖÆ¡±µÈ¡£

Ö÷ÒªÑо¿·½Ïò

ÄÉÃ×¼¼ÊõÔö¼ÓÄÑÈÜÐÔÒ©Îï¼°¶àëĵ°°×ÀàÒ©ÎïµÄ¿Ú·þÎüÊÕ£¬Ö×Áö°ÐÏòÄÉÃ×Ò©ÎïÊäËÍϵͳÑо¿¡£

´ú±íÐÔÂÛÎÄ

1. Xue-qing Wang, Jie-ming Fan, Ya-ou Liu, Bo Zhao, Zeng-rong Jia, Qiang Zhang*. Bioavailability and pharmacokinetics of sorafenib suspension, nanoparticles and nanomatrix for oral administration to rat. International Journal of Pharmaceutics. 2011, 419: 339-346.

2. Ya-Ou Liu, Jie-Ming Fan, Xue-Qing Wang*, Qiang Zhang. Preparation of sorafenib selfmicroemulsifying drug delivery system and its relative bioavailability in rats. Journal of Chinese Pharmaceutical Sciences. 2011, 20:164-170.

3. Wang Xueqing, Zhang Yuan, Pan Rong, He Rongqiao, Distribution of earthworm fibrinolytic enzyme in rat gastrointestinal tract after oral administration. Chinese Journal of New Drugs. 2010, 19: 1360-1364.

4. Xue-Qing Wang, Lan Chen, Rong Pan, Jing Zhao, Ying Liu, Rong-Qiao He, An earthworm protease cleaving serum fibronectin and decreasing HBeAg in HepG2.2.15 cells. BMC biochemistry. 2008, 9:30 doi:10.1186/1471-2091-9-30

5. Xue-Qing Wang, Jun-Dong Dai, Hua Zhang, Xuan Zhang,Jian-Cheng Wang, Qiang Zhang*. Absorption mechanism of cyclosporine A loaded pH-sensitive nanoparticles in rats. Journal of Nanoscience and Nanotechnology. 2008, 8:2422-2431.

6. Xue-qing Wang, Jia Huang, Jun-dong Dai, Tao Zhang, Wan-liang Lu,Hua Zhang, Xuan Zhang, Jian-cheng Wang, Qiang Zhang*. Long-term studies on the stability and oral bioavailability of cyclosporine A nanoparticle colloid. International Journal of Pharmaceutics£¬2006,322:146 -153.

7. Xue-qing Wang, Jun-dong Dai, Zhen Chen, Tao Zhang, Gui-min Xia, Qiang Zhang*. Bioavailability and Pharmacokinetics of Cyclosporine A loaded pH-sensitive nanoparticles for oral administration. Journal of Controlled Release, 2004, 97: 421-429.

8. Jun-dong Dai, Tsuneji Nagai, Xue-qing Wang, Tao Zhang, Meng Meng, Qiang Zhang*. pH-sensitive nanoparticles for improving the oral bioavailability of Cyclosporine A. International Journal of Pharmaceutics, 2004,280: 229 -240.

9.Yuan Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. Octreotide-Modified Polymeric Micelles as Potential Carriers for Targeted Docetaxel Delivery to Somatostatin Receptor Overexpressing Tumor Cells. Pharm Res. 2011, 28: 1167-1178.

10. Yu Xiang, Liang Liang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomes. Journal of Controlled Release. 2011,152: 402-410.

11. Zengrong Jia, Ping Lin, Yu Xiang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. A novel nanomatrix system consisted of colloidal silica and pH-sensitive polymethylacrylate improves the oral bioavailability of fenofibrate. European Journal of Pharmaceutics and Biopharmaceutics . 2011, 79: 126-134.

12. Junlin Zhang, Wu Jin, Xueqing Wang, Jiancheng Wang, Xuan Zhang and Qiang Zhang*. A Novel Octreotide Modified Lipid Vesicle Improved the Anticancer Efficacy of Doxorubicin in Somatostatin Receptor 2 Positive Tumor Models. Mol Pharm. 2010, 7:1159-68¡£

13. Wu CS, Wang XQ, Meng M, Li MG, Zhang H, Zhang X, Wang JC, Wu T, Nie WH, Zhang Q*. Effects of pH-sensitive nanoparticles prepared with different polymers on the distribution, adhesion and transition of Rhodamine 6G in the gut of rats. J Microencapsul. 2010, 27:205-217.

14. Wenbing Dai, Tingyuan Yang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*. PHSCNK-Modified and doxorubicin-loaded liposomes as a dual targeting system to integrin-overexpressing tumor neovasculature and tumor cells. Journal of Drug Targeting. 2009 (doi:10.3109/ 10611860903353354)¡£