öλÔÓéÀֵǼÈë¿ÚÏÂÔØ

µ¼Ê¦ÐÕÃû£ºÎ⹦ÐÛ
ÐÔ±ð£ºÄÐ
ÈËÆøÖ¸Êý£º65

ËùÊôԺУ£º¹ãÖÝÒ½¿Æ´óѧ
ËùÊôԺϵ£º
Ö°³Æ£º½ÌÊÚ
µ¼Ê¦ÀàÐÍ£ºË¶µ¼
ÕÐÉúöλÔÓéÀֵǼÈë¿ÚÏÂÔØ£ºÉñ¾­²¡Ñ§


¸öÈ˼òÊö :
Î⹦ÐÛ£¬ÄУ¬¹þ·ð´óѧҽѧԺJoslinҽѧÖÐÐÄÖúÀí½ÌÊÚ£¬¹ãÖÝÒ½¿Æ´óѧÌØƸ½ÌÊÚ¡£2007Äê»ñµÃЭºÍÓë¹þ·ð´óѧÁªºÏÅàÑø²©Ê¿Ñ§Î»¡£´Ó2005ÄêÆðÔÚ¹þ·ð´óѧҽѧԺ´ÓÊ¿ÆÑÐÑо¿¹¤×÷£¬Ò»Ö±´ÓÊÂÉñ¾­ËðÉËÓëÐÞ¸´£¬È±ÑªÐÔÄÔËðÉË¡¢ÐÄѪ¹Üϵ¼²²¡°üÀ¨¶¯ÂöÖàÑùÓ²»¯ºÍѪ¹Ü¶¯ÂöÁöµÈ¶à·½ÃæµÄ·Ö×Ó»úÖƺÍÏà¹ØÐźÅͨ·¼°Ò©Îï°ÐÏòÐÔµÄÑо¿£¬Ö÷ÒªÑо¿³É¹ûÔÚÓÚ·¢ÏÖÁ˲¹Ìåµ÷¿Øµ°°×CD59ºÍѪ½¬»º¼¤ëÄøµÈÖØÒªµ°°×·Ö×ÓÔÚÐÄÄÔѪ¹Ü¼²²¡µ±ÖеÄ×÷ÓúÍÆäеķÖ×Ó»úÖÆ£¬ÎªÐÄÄÔѪ¹Ü¼²²¡£¬È±ÑªÐÔÄÔËðÉ˼°Éñ¾­ËðÉ˵ÄÖÎÁÆÌṩÁËÒÀ¾ÝºÍ·½Ïò¡£ÔÚNature Neuroscience¡¢Nature Medicine¡¢ Circulation¡¢Circulation Research¡¢ Cancer ResearchµÈ¸ßˮƽÔÓÖ¾·¢±í¶àƪÑо¿ÐÔÂÛÎÄ¡£ÓÚ2012Äê»Ø¹ãÖÝÒ½¿Æ´óѧ´ÓÊÂÉñ¾­·Ö×ÓÉúÎïѧ¡¢È±ÑªÐÔÄÔËðÉË¡¢Éñ¾­ËðÉ˵ȼ²²¡µÄ·Ö×Ó»úÀíÑо¿¡£ÏÖΪMolecular pain¡¢Brain research¡¢Journal of Cardiothoracic and Vascular Anesthesia¡¢Circulation Research¡¢StrokeµÈ¹ú¼ÊÖªÃûÔÓÖ¾µÄÉó¸åÈË¡£±¾¿ÎÌâ×éÖÂÁ¦ÓÚÑо¿ÐÄÄÔѪ¹Ü¼²²¡»ù´¡Ñо¿£¬ÓÐ׏ú¼ÊÇ°ÔµµÄÊӽǡ£»¶Ó­ÓÐÖ¾Õß¼ÓÃËÎÒÃǵÄÍŶÓ¡£½üÆÚÂÛÎÄ[1]Wu G, Chen T, Shahsafaei A, Shi GP, Halperin JA, Qin X*. Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice. Circulation. 121:1338-1346. 2010[2]Wu G, Hu W, Shahsafaei A, Song WP, DobatTO M, Sukhova GK, Bronson RR, Shi GP, Rother R, Halperin JA, Qin X*. Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex. Circ Res. 84:65-70. 2009.[3]Wu LJ, Wu G, Akhavan Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP,? Clapham DE*. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci.? 15(4):565-73. 2012.[4]Hu W*, Ge X, You T, Xu T, Zhang J, Wu G, Peng Z, Chorev M, Halperin JA, Brown JR, Qin X.Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement -mediated cytolysis. Cancer Research. 71(6):2298-307. 2011.[5]Qin X*, Hu W, Song W, Blair P, Wu G, Hu X, Song Y, Bauer S, Feelisch M, Leopold JA, Loscalf:o J, Halperin JA. Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. Am J Hematol. 84(4):221-7.2009.[6]Hu, W. Ferris SP, Tweten RK, Wu G, Radaeva S, Gao B, Bronson RT, Halperin JA, Qin X*. Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin. Nat Med. 14:98-103. 2008.?

¿ÆÑй¤×÷ :
´ÓÊ¿ÆÑÐÑо¿¹¤×÷£¬Ò»Ö±´ÓÊÂÉñ¾­ËðÉËÓëÐÞ¸´£¬È±ÑªÐÔÄÔËðÉË¡¢ÐÄѪ¹Üϵ¼²²¡°üÀ¨¶¯ÂöÖàÑùÓ²»¯ºÍѪ¹Ü¶¯ÂöÁöµÈ¶à·½ÃæµÄ·Ö×Ó»úÖƺÍÏà¹ØÐźÅͨ·¼°Ò©Îï°ÐÏòÐÔµÄÑо¿£¬Ö÷ÒªÑо¿³É¹ûÔÚÓÚ·¢ÏÖÁ˲¹Ìåµ÷¿Øµ°°×CD59ºÍѪ½¬»º¼¤ëÄøµÈÖØÒªµ°°×·Ö×ÓÔÚÐÄÄÔѪ¹Ü¼²²¡µ±ÖеÄ×÷ÓúÍÆäеķÖ×Ó»úÖÆ£¬ÎªÐÄÄÔѪ¹Ü¼²²¡£¬È±ÑªÐÔÄÔËðÉ˼°Éñ¾­ËðÉ˵ÄÖÎÁÆÌṩÁËÒÀ¾ÝºÍ·½Ïò¡£ ·¢±í¶àƪÑо¿ÐÔÂÛÎÄ¡£

½ÌÓý±³¾° :
ѧϰ¾­Àú2004/09 ? 2007/07£¬¹þ·ðҽѧԺÓëЭºÍÒ½¿Æ´óѧÁªºÏÅàÑø£¬Éñ¾­ÉúÎïѧ²©Ê¿2001/09 ? 2004/07£¬ÖÐɽ´óѧҽѧԺ£¬Éñ¾­·Ö×ÓÉúÎïѧ˶ʿ1994/09 ? 1999/06£¬¹ãÖÝÒ½¿Æ´óѧ£¬ÁÙ´²Ò½Ñ§£¬Ñ§Ê¿ÅàÑøÌõ¼þ±¾¿ÎÌâ×éÅàÑøÑо¿ÉúµÄÖصãÅàÑøÄÚÈÝÊÇ£º»ù±¾¹¦±ØÐëÔúʵ¡¢Ð­×÷¾«Éñ±ØÐëÇ¿¡¢ÅàÑø¿ÆѧÑо¿ÐËȤ¡£