öλÔÓéÀֵǼÈë¿ÚÏÂÔØ

µ¼Ê¦ÐÕÃû£ºÏÄѧ·æ
ÐÔ±ð£ºÄÐ
ÈËÆøÖ¸Êý£º74

ËùÊôԺУ£º¹ãÖÝÒ½¿Æ´óѧ
ËùÊôԺϵ£º
Ö°³Æ£º½ÌÊÚ
µ¼Ê¦ÀàÐÍ£º²©µ¼
ÕÐÉúöλÔÓéÀֵǼÈë¿ÚÏÂÔØ£º¸¾²ú¿Æѧ


¸öÈ˼òÊö :
ÏÄѧ·æ£¬½ÌÊÚ£¬²©Ê¿Éúµ¼Ê¦¡£ÃÀ¹úTheMethodistHospitalResearchInstitute»ùÒò×éҽѧÖÐÐÄ£¨CenterforGenomicMedicine£©ºÍÌÇÄò²¡Ñо¿ÖÐÐÄ(CenterforDiabetesResearch)µÄÑо¿Ô±£¨Scientist£©¡£ÃÀ¹ú賦²¡Ð­»á(AGA)»áÔ±£¬ÃÀ¹ú¸ÎÔಡÑо¿Ð­»á£¨AASLD£©»áÔ±£¬ÃÀ¹úÄÚ·ÖÃÚѧ»á£¨TheEndocrineSociety£©»áÔ±¡£µ£ÈΡ¶Gastroenterology¡·¡¢¡¶Hepatology¡·¡¢¡¶Gut¡·¡¢¡¶AmericanJournalofPhysiology¡·¡¢¡¶AJP-GastrointestinalandLiverPhysiology¡·¡¢¡¶DigestiveandLiverDisease¡·µÈÔÓÖ¾Éó¸åÈË¡£1998-2002ÄêÓÚÃÀ¹ú±´ÀÕҽѧԺ£¨BaylorCollegeofMedicine£©Íê³ÉPostdoctoralAssociateÅàѵ£¬Ôøµ£ÈεÂÖÝ´óѧÐÝÊ¿¶ÙҽѧԺ£¨UniversityofTexasHealthScienceCenteratHouston£©Ò½Ñ§Ïµ½²Ê¦(Instructor)ºÍÖúÀí½ÌÊÚ£¨AssistantProfessor£©¡£ÒѾ­ÅàÑø²©Ê¿Ñо¿Éú2ÃûºÍ²©Ê¿ºóÑо¿Éú8Ãû¡£À¼ÖÝ´óѧÝÍÓ¢½²Ï°½ÌÊں͹ãÖÝҽѧԺÌØƸ½ÌÊÚ¡£Ö÷³ÖÍê³É¿ÎÌâ9Ï²ÎÓëÃÀ¹ú¹úÁ¢ÎÀÉúÑо¿Ëù£¨NIH£©ÏîÄ¿5Ï¼ÌÐø³Ðµ£NIH¿ÎÌâºÍÃÀ¹ú¹ú·À²¿¿ÎÌâ2ÏºÏ×÷¿ÆÑÐÏîÄ¿2Ï·¢±íProcNatlAcadSciUSA,Cell,JClinInvest,Oncogene,CircRes,JBiolChem¼°HeptologyÓеȸßˮƽѧÊõÆÚ¿¯ÂÛÎÄ40Óàƪ£¬Ôø¶à´ÎÊÜÑûÔÚA&MUniversitySystemHealthScienceCenter¡¢MDAndersonCancerCenter,UniversityofHouston¡¢ÖÐÄÏ´óѧ¡¢¹ãÖÝҽѧԺ¡¢»ª¶«Ê¦·¶´óѧ¡¢ÎÂÖÝҽѧԺ¡¢À¼ÖÝ´óѧ¼°ÆäËû¿ÆÑлú¹¹×öרÌⱨ¸æ£¬²¢¶à´Î²Î¼Ó¹ú¼Ê»áÒé½»Á÷²¢´ó»á·¢ÑÔ£¬ÂÛÎÄ»ñ´ó»á°ä½±¡£2011Äê×÷ΪÌØÑû¼Î±öÔÚ¶«·½ÄÚ·ÖÃÚ-ÌÇÄò²¡ÂÛ̳ºÍÖлªÄÚ·ÖÃÚÄê»á´ó»á±¨¸æ¡£´Óʺ˼¤ËØÊÜÌ壨NuclearHormoneReceptor£©ÔÚÖ×Áö¡¢ÈËÌå´úл£¬ÉúÖ³ÄÚ·ÖÃÚµ÷¿Ø£¬¼°¸Îµ¨¼²²¡ºÍÉöÔ༲²¡µÈÁìÓòµÄ´´ÐÂÐÔÑо¿£¬²¢È¡µÃ׿ÖøµÄ³É¼¨¡£?

¿ÆÑй¤×÷ :
²¿·Ö·¢±íµÄÂÛÎÄ£º?XiaX,JungD,WebbP,ZhangA,ZhangB,LiL,AyersSD,GabbieC,UenoY,GustafssoneJ,AlpiniG,MooreDD,LeSageGD.?LiverXReceptor¦ÂandPeroxisomeProliferator-ActivatedReceptor¦Äregulatecholesteroltransportincholangiocytes.????Hepatology.?2012Jun22.doi:10.1002/hep.25919.[Epubaheadofprint]YuB,LinH,YangL,ChenK,LuoH,LiuJ,GaoX,XiaX,HuangZ.GeneticvariationinNRF2-AREpathwayassociateswithdefectivespermatogenesisinhumans.?JMolMed(Berl).2012May31.[Epubaheadofprint]WangF,YuB,YangW,LiuJ,LuJ,XiaX.Polycysticovarysyndromeresemblinghistopathologicalalterationsinovariesfromprenatalandrogenizedfemalerats.?JOvarianRes.2012May185(1):15.[Epubaheadofprint]LiL,ZhangX,ZhaoL,XiaX,WangW.??ComparisonofDNAapoptosisinmouseandhumanblastocystsaftervitrificationandslowfreezing.?MolReprodDev.2012Feb1,79:229?236?ZhouY,TozziF,ChenJ,FanF,XiaL,WangJ,GaoG,ZhangA,XiaX,BrasherH,WidgerW,EllisLM,WeihuaZ.?IntracellularATPlevelsareapivotaldeterminantofchemoresistanceincoloncancercells.?CancerRes.2012Jan172(1):304-14.?SandulacheVC,SkinnerHD,OwTJ,ZhangA,XiaX,LuchakJM,WongLJ,PickeringCR,ZhouG,MyersJN.???Individualizinganti-metabolictreatmentstrategiesforheadandnecksquamouscellcarcinomabasedonTP53mutationalstatus.?Cancer.2012Feb1118(3):711-21.?DengT,SieglaffDH,ZhangA,LyonCJ,AyersSD,CvoroA,GupteAA,XiaX,BaxterJD,WebbP,HsuehWA.???Aperoxisomeproliferatoractivatedreceptor(PPAR)/PPARcoactivator1¦Âautoregulatoryloopinadipocytemitochondrialfunction.JBiolChem.2011Sep2286(35):30723CollinsAR,LyonCJ,XiaX,LiuJZ,TangiralaRK,YinF,BoyadjianR,BikineyevaA,Pratic¨°D,HarrisonDG,HsuehWA.Age-acceleratedatherosclerosiscorrelateswithfailuretoupregulateantioxidantgenes.CircRes.2009Mar27104(6):e42-54.ZhongX,LiuH,PuA,XiaX,ZhouX.Mcellsareinvolvedinpathogenesisofhumancontactlens-associatedgiantpapillaryconjunctivitis.ArchImmunolTherExp(Warsz).2007May55(3):173-7.?ZhangW,XiaX,ReisenauerMR,VallonV,LangF,KuhlD,KoneBC.Aldosterone-inducedSGK1PhosphorylatesAF9andRelieves?Dot1a-AF9-MediatedTranscriptionalRepressionofENaCalpha.??JClinInvest.2007Mar117(3):773-83.?ZhangW,XiaX,ReisenauerMR,HemenwayCS,KoneBC.DOT1a-AF9complexmediateshistoneH3K79hypermethylationandrepressionofENaC¦Áinanaldosterone-sensitivemanner.?JBiolChem.2006Jun30281(26):18059-68.?MaW,XiaX,StaffordLJ,YuC,WangF,LeSageG,LiuM.ExpressionofGCIPintransgenicmicedecreasessusceptibilitytochemicalhepatocarcinogenesis.?Oncogene.2006Jul1325(30):4207-16.ZhangW,XiaX,JalalDI,KuncewiczT,XuW,LeSageGD,KoneBC.??Aldosterone-sensitiverepressionofENaC¦ÁtranscriptionbyahistoneH3lysine-79methyltransferase.AmJPhysiolCellPhysiol.2006Mar290(3):C936-46.?AlpiniG,GlaserS,BaiocchiL,FrancisH,XiaX,LeSageG.???SecretinactivationoftheapicalNa(+)-dependentbileacidtransporterisassociatedwithcholehepaticshuntinginrats.??Hepatology.2005May41(5):1037-45.??YuZ,XiaX,KoneB.?ExpressionProfileofaHumanInducibleNitricOxideSynthasePromoter-ReporterInTransgenicMiceDuringEndotoxemia.?AmJPhysiolRenalPhysiol.2005Jan288(1):F214-20.?XiaX,RoundtreeM,MerikhiA,LuX,ShentuS,LeSageG.??DegradationoftheApicalSodium-dependentBileAcidTransporter(ASBT)bytheUbiquitin-ProteasomePathwayinCholangiocytes.?JBiolChem.**(43):44931-44937.?ZhangW,XiaX,ZouL,XuX,LeSageGD,andKoneBC.??InVivoExpressionProfileofanH+-K+-ATPase2SubunitPromoter-reporterTransgene.??????JPhysiolRenalPhysiol.2004Jun286(6):F1171-77.?QyangY,ChambersSM,WangP,XiaX,ChenX,GoodellMA,ZhengH.??Myeloproliferativediseaseinmicewithreducedpresenilingenedosage:effectofgamma-secretaseblockage.?Biochemistry.2004May1143(18):5352-9.?KangDE,SorianoS,XiaX,EberhartCG,DeStrooperB,ZhengH,KooED.Presenilincouplesthepairedphosphorylationofbeta-cateninindependentofaxin:implicationsforbeta-cateninactivationintumorigenesis.??Cell.2002Sep20110(6):751-62.XiaX,WangP,SunX,SorianoS,ShumWK,YamaguchiH,TrumbauerME,TakashimaA,KooEH,ZhengH.Theaspartate-257ofpresenilin1isindispensableformousedevelopmentandproductionofbeta-amyloidpeptidesthroughbeta-catenin-independentmechanisms.ProcNatlAcadSciUSA.2002Jun2599(13):8760-5.?MoehlmannT,WinklerE,XiaX,EdbauerD,MurrellJ,CapellA,KaetherC,ZhengH,GhettiB,HaassC,SteinerH.Presenilin-1mutationsofleucine166equallyaffectthegenerationoftheNotchandAPPintracellulardomainsindependentoftheireffectonAbeta42production.ProcNatlAcadSciUSA.2002Jun1199(12):8025-30.?DineleyKT,XiaX,BuiD,SweattJD,ZhengH.?Acceleratedplaqueaccumulation,associativelearningdeficits,andup-regulationofalpha7nicotinicreceptorproteinintransgenicmiceco-expressingmutanthumanpresenilin1andamyloidprecursorproteins.?JBiolChem.2002Jun21277(25):22768-80.?XiaX,QianS,SorianoS,WuY,FletcherAM,WangXJ,KooE,WuX,ZhengH.Lossofpresenilin1isassociatedwithenhancedbeta-cateninsignalingandskintumorigenesis.???ProcNatlAcadSciUSA.2001Sep1198(19):10863-8.?Books,BookChaptersandReviews?XiaX,FrancisH,GlaserS,AlpiniG,LeSageG.Bileacidinteractionswithcholangiocytes.WorldJGastroenterol.200612(22):3553-3563.?XiaX,DeMorrowS,MarzioniM,FavaG,FrancisH,AlpiniG,GlaserS,LeSageG.CholangiocyteInjuryandDuctopenicSyndromes.SeminLiverDis.2007Nov27(4):401-12.XiaX,AlpiniG,LeSageG.???¡°ExtrahepatocyticTransportofBileAcids:TheRoleoftheCholangiocyte¡±.In:KepplerD,BeuersU,LeuschnerU,StiehlA,TraunerM,PaumgartnerG,eds.Bileacids:biologicalactionsandclinicalrelevance.ProceedingsoftheFalkSymposium**Oct6-7Freiberg(Germany).Dordrecht(TheNetherlands):Springer2007:71-75XiaX,LeSageG.,¡°Bileacidsandcholangiocytebiology¡±inPathophysiologyoftheIntrahepaticBiliaryEpithelium.??2008:ISBN:978-81-7895-337-3??TransworldResearchNetwork37/661(2),FortP.O.,Trivandrum-695023,Kerala,India???2009:1-20?