öλÔÓéÀֵǼÈë¿ÚÏÂÔØ

µ¼Ê¦ÐÕÃû£ºÏò»ª
ÐÔ±ð£ºÅ®
ÈËÆøÖ¸Êý£º177

ËùÊôԺУ£ºÖйúÒ©¿Æ´óѧ
ËùÊôԺϵ£ºÒ©Ñ§Ôº
Ö°³Æ£º½ÌÊÚ
µ¼Ê¦ÀàÐÍ£º²©µ¼
ÕÐÉúöλÔÓéÀֵǼÈë¿ÚÏÂÔØ£ºÒ©Îﻯѧ¡¢Ò©Ñ§£¨¹¤ÒµÒ©Ñ§·½Ïò£©
Ñо¿ÁìÓò£º Ö÷Òª´ÓÊ¿¹Ö×ÁöºÍ¿¹´úлÐÔ¼²²¡Ò©ÎïÑо¿£¬Öص㿪չÓëÐÔ¼¤ËØ´úлÎÉÂÒÓйصÄÖ×Áö£¨ÈéÏÙ°©¡¢×Ó¹¬ÄÚĤ... [Õ¹¿ª]


Ñо¿ÁìÓò£º Ö÷Òª´ÓÊ¿¹Ö×ÁöºÍ¿¹´úлÐÔ¼²²¡Ò©ÎïÑо¿£¬Öص㿪չÓëÐÔ¼¤ËØ´úлÎÉÂÒÓйصÄÖ×Áö£¨ÈéÏÙ°©¡¢×Ó¹¬ÄÚĤ°©¡¢Âѳ²°©¡¢Ç°ÁÐÏÙ°©µÈ£©ºÍÀÏÄ겡£¨¸üÄêÆÚ¹ÇÖÊÊèËÉ¡¢Á¼ÐÔÇ°ÁÐÏÙÔöÉú¡¢ÑªÖ¬Òì³£¡¢IIÐÍÌÇÄò²¡µÈ£©ÖÎÁÆÒ©ÎïµÄÑо¿Ó뿪·¢£»´ËÍ⣬»¹´ÓÊÂçÞÌåÐÂÒ©¿ª·¢¼°ÀÏÆ·Öֺϳɹ¤ÒոĽø¡¢çÞÌåÐÂ×ÊÔ´µÄ¿ª·¢ºÍÀûÓᣠ[ÊÕÆð]




ͨѶ·½Ê½ :
°ì¹«µç»°£º**
µç×ÓÓʼþ£ºcpuxianghua@163.com
ͨѶµØÖ·£ºÄϾ©ÊÐͯ¼ÒÏï24ºÅ£¬ÖйúÒ©¿Æ´óѧҩѧԺҩÎﻯѧ½ÌÑÐÊÒ£¬Óʱà210009


¿ÆÑй¤×÷ :
³Ðµ£¿ÆÑÐÏîÄ¿£º1. Ö÷³Ö¹ú¼Ò×ÔÈ»¿Æѧ»ù½ðÃæÉÏÏîÄ¿£¨ER/VEGFRË«°Ðµã¿¹ÈéÏÙ°©Ò©ÎïÑо¿£¬**£©£»2. Ö÷³Ö¿Æ¼¼²¿¡°ÖØ´óÐÂÒ©´´ÖÆ¡±¿Æ¼¼ÖØ´óרÏµ÷Ѫ֬ºòÑ¡Ò©Ñо¿£¬2012ZX**-041£©£»3. Ö÷³Ö½­ËÕÊ¡¿Æ¼¼Ö§³Å¼Æ»®-Éç»á·¢Õ¹ÏîÄ¿£¨¿¹ÈéÏÙ°©Ò©ÎïÑо¿£¬BE**£©£»4. Ö÷³Ö½­ËÕÊ¡¡°Áù´óÈ˲Ÿ߷塱ÏîÄ¿£¨»ùÓÚCETPµÄµ÷Ѫ֬ҩÎï·Ö×Ó·¢ÏÖ¼°»îÐÔÑо¿£¬2013-YY003£©£»5. Ö÷³ÖÄϾ©ÊÐ321Áì¾üÐͿƼ¼´´ÒµÈ˲żƻ®ÏîÄ¿£º´´ÐÂÒ©Îï¼°Ò½Ò©ÖмäÌåÑз¢¼°²úÒµ»¯£»6. Ö÷³Ö½­ËÕÊ¡¹ú¼ÊºÏ×÷ÏîÄ¿£¨SERM»¯ºÏÎïÉè¼Æ¡¢ºÏ³É¼°ÉúÎï»îÐÔ£¬BZ**£©£»7. Ö÷³Ö¹ú¼Ò·¢¸ÄίÎ÷²¿¸ß¼¼Êõ²úÒµ»¯Ê¾·¶¹¤³Ì×ÓÏެÊh¶þÏ©ÎïºÏ³ÉçÞÌ弤ËØÒ©ÎïµÄÑо¿£»8. ²Î¼Ó¿Æ¼¼²¿¡°ÖØ´óÐÂÒ©´´ÖÆ¡±¿Æ¼¼ÖØ´óרÏ¿¹ÈéÏÙ°©ºòÑ¡Ò©Î2012ZX**-048£©£»9. ²Î¼Ó¹ú¼Ò×ÔÈ»»ù½ðÖصãÏîÄ¿£¨¾ßÓÐNRF2-Keap1µ°°×-µ°°×Ï໥µ÷¿Ø×÷ÓõÄÀàÌìÈ»²úÎïÑо¿£¬**£©¡£10. Óë¶à¼ÒçÞÌ弤ËØÖÆÒ©ÆóÒµºÏ×÷£¬Ö÷³Ö¶àÏîÐÂÒ©Ñо¿ÏîÄ¿£¬×÷ΪÏîÄ¿¸ºÔðÈË»ñµÃÐÂÒ©Ö¤ÊéÈý±¾£¬¸ºÔ𿪷¢µÄ¶à¸öÔ­ÁÏÒ©Æ·ÖÖͶ·ÅÉú²ú¡£
½üÆÚÂÛÎÄ£º1.Xinge Zhao, Minhang Xin, Yazhou Wang, Wei Huang, Qiu Jin, Feng Tang, Gang Wu, Yong Zhao, Hua Xiang*. Discovery of thieno [3,2-c]pyridin-4-amines as novel Bruton¡¯s tyrosine kinase (BTK) inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(17): 6059-60682.Wenbin Wang, Yi He, Pei Xu, Qidong You, Hong Xiao, Hua Xiang*. Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities. Bioorganic & Medicinal Chemistry, 2015, 23 (15): 4428-44333.Xinge Zhao, Wei Huang, Yazhou Wang, Minhang Xin, Qiu Jin, Jianfeng Cai, Feng Tang, Yong Zhao, Hua Xiang*. Pyrrolo [2,3-b]pyridine derivatives as potent Bruton¡¯s tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(15): 4344-43534.Xinge Zhao, Wei Huang, Yazhou Wang, Minhang Xin, Qiu Jin, Jianfeng Cai, Feng Tang, Yong Zhao, Hua Xiang*. Discovery of novel Bruton¡¯s tyrosine kinase (BTK) inhibitors bearing a pyrrolo [2,3-d]pyrimidine scaffold. Bioorganic & Medicinal Chemistry, 2015, 23(4): 891-9015.Xinge Zhao, Minhang Xin, Wei Huang, Yanliang Ren, Qiu Jin, Feng Tang, Hailong Jiang, Yazhou Wang, Jie Yang, Shifu Mo, Hua Xiang*. Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton¡¯s tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(2): 348-3646.Tang ZC, Niu SX, Liu F, Lao KJ, Miao JS, Ji JZ, Wang X, Yan M, Zhang LY, You QD, Xiao H, Xiang H*. Synthesis and biological evaluation of 2, 3-diaryl isoquinolinone derivatives as anti-breast cancer agents targeting ER¦Á and VEGFR-2. Bioorg Med Chem Lett. 2014, 24(9): 2129-2133

½ÌÓý±³¾° :
1985.7 ËÄ´¨´óѧ»¯Ñ§ÏµÓлú»¯Ñ§öλÔÓéÀֵǼÈë¿ÚÏÂÔØѧʿ£»1988.7 ËÄ´¨´óѧ»¯Ñ§ÏµÓлú·ÖÎööλÔÓéÀֵǼÈë¿ÚÏÂÔØ˶ʿ£»2003.12 ÖйúÒ©¿Æ´óѧҩѧԺҩÎﻯѧöλÔÓéÀֵǼÈë¿ÚÏÂÔز©Ê¿£»2002.8-2003.9 Institute of Organic Chemistry, University of Tuebingen, Germany £¨µÂ¹úµÙ±ö¸ù´óѧ²©Ê¿ÁªºÏÅàÑø£©£»2014.9-2015.9 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, USA (ÃÀ¹úÂéÊ¡Àí¹¤Ñ§Ôº·ÃÎÊѧÕß)¡£