öλÔÓéÀֵǼÈë¿ÚÏÂÔØ

µ¼Ê¦ÐÕÃû£º½ðº£Ïþ
ÐÔ±ð£ºÅ®
ÈËÆøÖ¸Êý£º501

ËùÊôԺУ£ºÄþ²¨´óѧ
ËùÊôԺϵ£ºº£ÑóѧԺ
Ö°³Æ£º¸±½ÌÊÚ
µ¼Ê¦ÀàÐÍ£º
ÕÐÉúöλÔÓéÀֵǼÈë¿ÚÏÂÔØ£ºº£ÑóÉúÎïѧ
Ñо¿ÁìÓò£º º£ÑóÒ©Îï/º£ÑóÉúÎïѧ
Ñо¿ÁìÓò£º º£ÑóÒ©Îï/º£ÑóÉúÎïѧ [ÊÕÆð]




ͨѶ·½Ê½ :
µç×ÓÓʼþ£ºjinhaixiao@nbu.edu.cn


¸öÈ˼òÊö :
ÐÕÃû

½ðº£Ïþ
¹¤×÷µ¥Î»

Äþ²¨´óѧº£ÑóѧԺÉúÎïÓ뺣Ñó¿Æѧϵ

Ö°³Æ

¸±½ÌÊÚ

ͨÐŵØÖ·

315211 Äþ²¨Êн­±±Çø·ç»ªÂ·818ºÅ

µç»°¡¢´«Õæ¡¢E-mail

**£¬**£»jinhaixiao@nbu.edu.cn

¸öÈ˼ò½é

1978Äê12Ô³öÉú£¬¸±½ÌÊÚ£¬Ë¶Ê¿Éúµ¼Ê¦¡£2007Äê±ÏÒµÓÚÕã½­´óѧ»¯Ñ§ÉúÎïѧöλÔÓéÀֵǼÈë¿ÚÏÂÔØ£¬»ñ²©Ê¿Ñ§Î»¡£2010Äê3ÔÂ~2010Äê9ÔÂÔÚÖйú¿ÆѧԺÉϺ£Ò©ÎïËù½»Á÷£¬2013Äê1ÔÂ~2014Äê1Ô£¬Ð¼ÓƹúÁ¢´óѧҩѧԺ½»Á÷¡£

»ñ½±ÓëÈÙÓþ³ÆºÅ

2010Äê У¼¶ÓÅÐã°àÖ÷ÈÎ

2011Äê У¼¶ÓÅÐã°àÖ÷ÈÎ

2012Äê Ôº¼¶ÓÅÐã°àÖ÷ÈÎ

2013Äê У¼¶ÓÅÐã°àÖ÷ÈÎ

2012Äê 2012ÄêÄþ²¨´óѧÓÅÐãÇàÄê½Ìʦ¿ÆÑд´Ð½± ÈýµÈ½±

»ñÊÚȨ·¢Ã÷רÀû1Ï²ÎÓë³ö°æ±àÖø1²¿£¬·¢±í30ÓàƪÎÄÕ£¬ÆäÖеÚÒ»×÷Õß·¢±íSCI 10ƪ¡£

Ö÷ÒªÑÐ

¾¿·½Ïò

»ùÓڰе㵰°×½á¹¹µÄÒ©Îï·Ö×ÓÉè¼Æ£¬°Ðµãµ°°×µÄ¶¯Ì¬Ä£Ä⣬°Ðµãµ°°×µÄ¿Ë¡±í´ïºÍÒÖÖƼÁµÄÒ©ÀíÆÀ¼Û¡£

ÊÚȨ·¢Ã÷רÀû

1.Ò»ÖÖÉ«°·ÑÜÉúÎïÀ໯ºÏÎï¼°ÆäÖƱ¸·½·¨ºÍÓÃ;¡£2015.8


¿ÆÑй¤×÷ :
´ú±íÐÔ

ÂÛÎÄ

Jin HX, Go ML, Yin P, Qiu XT, Zhu P, Yan XJ. Determining the functions of HIV-1 Tat and a second magnesium ion in the CDK9/cyclin T1 complex: a molecular dynamics simulation study. PLOS ONE. DOI: 10.1371/journal. pone. **

Yang T, Chen X, Jin HX, Sethi G, Go ML. Functionalized tetrahydro-1H-pyrido[4,3-b]indoles: A novel chemtope with Sirtuin 2 inhibitory activity. Eur J Med Chem. 2015, 92,145-155.

Tan KL, Ali A, Du Y, Fu H, Jin HX, Chin TM, Khan M, Go ML. Synthesis and Evaluation of Bisbenzylidenedioxotetrahydrothiopranones as Activators of Endoplasmic Reticulum (ER) Stress Signaling Pathways and Apoptotic Cell Death in Acute Promyelocytic Leukemic Cells. J Med Chem 2014, 57(14), 5904-5918.

·½½££¬ºÎ¿ý·¼£¬¼¾Èü£¬ÖìÅô£¬½ðº£Ïþ£¬ÑÏС¾ü£¬Î¢ÄÒÔ嶾ËØÑÜÉúÎïµÄ»¯Ñ§Ã¸·¨ºÏ³É¼°»îÐÔÆÀ¼Û£¬ÖйúÉúÎﻯѧÓë·Ö×ÓÉúÎïѧ±¨£¬2014£¬30£¨7£©£º706-713.

Jin H, Nguyen T, Mei-Lin G. Acetylcholinesterase and Butyrylcholinesterase Inhibitory Properties of Functionalized Tetrahydroacri-dines and Related Analogs. Med chem, 2014, 4: 688-696.

Cai BQ, Jin HX*, Chen YD, Zhu P, Yan XJ. 3D-QSAR and 3D-QSSR studies of Thieno [2,3-d]pyrimidin-4-yl Hydrazone analogues as CDK4 inhibitors by CoMFA analysis. Acta Pharmacologica Sinica.2014, 35(1):151-160

Huang Q$, Jin H$, Liu Q, Wu Q, Kang H, Cao Z, Zhu R.Proteochemometric modeling of the bioactivity spectra of HIV-1 protease inhibitors by introducing protein-ligand interaction fingerprint. PLoS One. 2012,7(7),e41698£¨co-first author£©

Jin HX, Zhang B, Jun YX, Xu JL, Tan VBC. Influences of phosphorylation on Thr14/Tyr15 in CDK5 in the presence of roscovitine/ATP and HHASPRK. Molecular Simulation, 2012,38(3):248-257

½ðº£Ïþ£¬ÑÏС¾ü£¬ÖìÅô£¬PKAø¼°ÆäÒÖÖƼÁbalanolµÄ¼ÆË㻯ѧ£¬»¯Ñ§½øÕ¹£¬2010£¬Vol.22, 993-1001

½ðº£Ïþ£¬ÎâÌìÐÇ£¬ÑÏС¾ü£¬½¯Ó¾ü£¬×Þ½¨ÎÀ£¬ÒÖÖƼÁBD2¶ÔPKAÓëPKC ¦ÂIIµÄÒÖÖÆÑ¡ÔñÐÔÑо¿£¬»¯Ñ§Ñ§±¨£¬2009£¬Vol.67, 1487-1491

Jin HX, Wu TX, Jiang YJ, Zou JW, Zhuang SL, Mao X, Yu QS, role of phosphorylated Thr-197 in the catalytic subunit of cAMP-dependent protein kinase, Journal of Molecular Structure:THEOCHEM 2007, 805,9-15

Jin HX, Wu TX, Jiang YJ, Zou JW, Zhuang SL, Mao X, Yu QS, Functional role of three water molecules buried within catalytic subunit of cAMP-dependent protein kinase, Journal of Molecular Structure:THEOCHEM 2007,809,21-27

½ðº£Ïþ£¬ºú¹ðÏ㣬ÎâÌìÐÇ£¬ÉÌÖ¾²Å£¬×Þ½¨ÎÀ£¬ÓáÇìÉ­£¬Ò©ÎïË®Èܽâ¶ÈµÄQSARÑо¿ºÍVolSurf²ÎÊý£¬½á¹¹»¯Ñ§£¬2004£¬Vol.23, 452-458.
³Ðµ£Ö÷Òª¿ÎÌâ

Ö÷³ÖµÄ¿ÎÌâ°üÀ¨£º¹ú¼Ò×ÔÈ»¿Æѧ»ù½ð¡¶¿¹°©º£ÃàÌìÈ»²úÎïfascaplysinÐÂÑÜÉúÎïµÄ°ÐÏòÉè¼Æ¡¢ºÏ³ÉºÍÉúÎï»îÐÔÆÀ¼Û¡·£¬Ê¡´´ÐÂÍŶÓ×ÓÏîÄ¿¡¶¿¹Ö×Áöº£ÑóÉúÎï¼îµÄÑÐÖÆÓ뿪·¢¡·£¬Ñ§Ð£È˲Żù½ð¡¶PKCµÄͬԴģ½¨¼°ÒÖÖƼÁBD2¶ÔPKAÓëPKCµÄÑ¡ÔñÐÔÑо¿¡·£¬Äþ²¨ÊÐ×ÔÈ»¿Æѧ»ù½ð¡¶»ùÓÚCDK°ÐÏòµÄº£ÑóÌìÈ»²úÎï½áºÏģʽ·ÖÎöÓë½á¹¹¸ÄÔì¡·£¬Ñ§¿ÆÏîÄ¿¡¶Ï¸°ûÖÜÆÚµ°°×¼¤Ã¸CDKÒÖÖƼÁµÄQSARÑо¿¡·Ñ§Ð£¿ÆÑлù½ð£¨Àí£©¡¶CDK5Ó뺣ÑóÌìÈ»²úÎïhymenialdisineºÍMeriolinµÄ·Ö×Ó¶Ô½ÓÓëQSARÑо¿¡·µÈ
ÊÚȨ·¢Ã÷רÀû

1.Ò»ÖÖÉ«°·ÑÜÉúÎïÀ໯ºÏÎï¼°ÆäÖƱ¸·½·¨ºÍÓÃ;¡£2015.8