öλÔÓéÀֵǼÈë¿ÚÏÂÔØ

µ¼Ê¦ÐÕÃû£ºÒ×¹â»Ô
ÐÔ±ð£ºÄÐ
ÈËÆøÖ¸Êý£º409

ËùÊôԺУ£ºÄÏ»ª´óѧ
ËùÊôԺϵ£ºÒ½Ñ§Ôº
Ö°³Æ£º½ÌÊÚ
µ¼Ê¦ÀàÐÍ£º
ÕÐÉúöλÔÓéÀֵǼÈë¿ÚÏÂÔØ£º»ù´¡Ò½Ñ§


ͨѶ·½Ê½ :
°ì¹«µç»°£º**
µç×ÓÓʼþ£ºghyi6108@163.com
ͨѶµØÖ·£ººâÑôÊг£Ê¤Î÷·28ºÅÄÏ»ª´óѧ±±Ô·


¸öÈ˼òÊö :
1. ¡°L-¾«°±Ëá/Ò»Ñõ»¯µª¿¹¶¯ÂöÖàÑùÓ²»¯×÷Óü°Æä»úÀíµÄÑо¿¡±£¬»ñ¹ú¼ÒÎÀÉú²¿Ò½Ò©ÎÀÉú¿Æ¼¼½ø²½¶þµÈ½±£¨5£©£¬1999Äê¡£2. ¡°L-¾«°±Ëá/Ò»Ñõ»¯µª¿¹¶¯ÂöÖàÑùÓ²»¯¼°Æä»úÀíµÄÑо¿¡±£¬»ñºþÄÏÊ¡¿Æ¼¼½ø²½ÈýµÈ½±£¨5£©£¬1998Äê¡£3. ¡°NO-1886µ÷½ÚÌÇ´úлºÍÖ¬´úлµÄ×÷Óü°»úÖÆ¡±£¬»ñºþÄÏÊ¡¿Æѧ¼¼Êõ½ø²½ÈýµÈ½±£¨5£©£¬2006Äê4. ¡°ÒÔABCA1Ϊ°Ðµã·ÀÖζ¯ÂöÖàÑùÓ²»¯·¢Éú·¢Õ¹¡±£¬»ñºþÄÏʡҽѧ¿Æ¼¼³É¹û¶þµÈ½±£¨6£©£¬2009Äê5. ¡°ÒÔABCA1Ϊ°Ðµã·ÀÖζ¯ÂöÖàÑùÓ²»¯·¢Éú·¢Õ¹¡±£¬ºþÄÏÊ¡×ÔÈ»¿Æѧ½±ÈýµÈ½±£¨6£©£¬2013Äê

¿ÆÑй¤×÷ :
1984.07¡ª2000.08£¬ºâÑôҽѧԺ Öú½Ì¡¢½²Ê¦¡¢¸±½ÌÊÚ¡£2000.09¡ª2003.07£¬ÄÏ»ª´óѧÐÄѪ¹Ü¼²²¡Ñо¿Ëù¸±½ÌÊÚ¡¢¸±Ëù³¤¡£2003.08¡ª2007.11£¬ÄÏ»ª´óѧÐÄѪ¹Ü¼²²¡Ñо¿Ëù½ÌÊÚ¡¢¸±Ëù³¤¡£2007.12¡ª2008.12£¬¼ÓÄôóä×Ì«»ª´óѧÐÄÔàÑо¿Ëù·ÃÎÊѧÕß¡£2009.01¡ªÏÖÔÚ£¬ÄÏ»ª´óѧҽѧԺ½ÌÊÚ¡¢»úÄÜѧʵÑéÖÐÐÄÖ÷ÈΡ£1. Mo ZC, Ren K, Liu X, Tang ZL, Yi GH*. A high-density lipoprotein-mediated drug delivery system. Adv Drug Deliv Rev. 2016 May 18. pii: S0169-409X(16)30140-5. doi: 10.1016/j.addr.2016.04.030. [Epub ahead of print] Review2. Li YB, Zhang QH, Chen Z, He ZJ, Yi GH*. Oxidized low-density lipoprotein attenuated desmoglein 1 and desmocollin 2 expression via LOX-1/Ca(2+)/PKC-¦Â signal in human umbilical vein endothelial cells. BiochemBiophys Res Commun. 2015 Dec 4468(1-2):380-6. doi: 10.1016/j.bbrc.2015.10.079. Epub 2015 Oct 20 PMID: ** 3. Ren K, Tang ZL, Jiang Y, Tan YM, Yi GH*. Apolipoprotein M. ClinChimActa. 2015 Jun 15446:21-9. doi: 10.1016/j.cca.2015.03.038. Epub 2015 Apr 7. Review4. Wu R, Zhang QH, Lu YJ, Ren K, Yi GH*. Involvement of the IRE1¦Á-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic Diseases. DNA Cell Biol. 2015Jan 1 34(1): 6-18. [Epub ahead of print]5. ĪÖгÉ, Å·º¬Ð¦, Ò×¹â»Ô*. ÔØÖ¬µ°°×A-¢ñÔÚ¸ßÃܶÈÖ¬µ°°×ÉúÎïºÏ³ÉÖеÄ×÷ÓÃÑо¿½øÕ¹. ÉúÎïÎïÀíÓëÉúÎﻯѧ½øÕ¹. 2015£»42£¨9£©£º788-795. DOI: 10.16476/j.pibb.2015.01096. ÈÎÀ¤, ÌÆÕñÀö, Ò×¹â»Ô*. ÔØÖ¬µ°°×M. ÖйúÉúÎﻯѧÓë·Ö×ÓÉúÎïѧ±¨. 2015£»31£¨6£©£º557-565. DOI: 10. 13865 /j.cnki.cjbmb.2015.06.027. ³ÑÞ¾Õ, ÍõË«, ÎéÈÙ, Ò×¹â»Ô*. S1P /S1PR2 µÄÐÄѪ¹Üµ÷½Ú×÷Óü°ÆäÐźÅͨ·. ÖйúÐÄѪ¹ÜÔÓÖ¾. 2015£»20£¨2£©£º158-160. DOI: 10.3969 /j.issn.1007-5410.2015.02.0208. Xiongshenglin, Liu xing, Yi Guanghui*. High-density lipoprotein induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through sphingosine kinase-2. Mol Cell Biochem2014 Apr 20 389(1-2):197-207SCI9. ĪÖгÉ, Àîϼ, ÕÅ´óé¦,ÖìÃ÷Ñà,ÕÅÇຣ,ÔøÓ±,ÎéÈÙ,³ÑÞ¾Õ,³ÂÒâ,Ò×¹â»Ô*. GW50156ͨ¹ýTGFbeta-Smad3ÐźÅ;¾¶´Ù½øÈËÆê¾²ÂöÄÚƤϸ°ûPAI-1µÄ±í´ï.ÉúÎﻯѧÓëÉúÎïÎïÀí½øÕ¹2014 41£¨7£©£º674-68110. Ì·ÓñÁÖ£¬ÔøÓ±£¬ÄªÖгÉ£¬ÂÀÔ˳É£¬ºÎƽƽ£¬Å·ÑôÐÂƽ£¬Ò¦·å£¬Ð»Î¡£¬ÌƳ¯¿Ë£¬Ò×¹â»Ô*. PPAR¦Ã¶Ô¸ßÌÇÓÕµ¼THP-1¾ÞÊÉϸ°ûCD36±í´ï¼°Ö¬ÖÊÐî»ýµÄµ÷½Ú. ÖйúÏÖ´úҽѧÔÓÖ¾. 2014£»24£¨30£©£º18-2311. Ì·ÓñÁÖ,ÔøÓ±,ĪÖгÉ,Ò×¹â»Ô*. ¸ßÌÇÒÀÀµ¹ýÑõ»¯ÌåÔöÖ³ÎＤ»îÐÍÊÜÌå¦Ã½éµ¼THP-1¾ÞÊÉϸ°ûCD36±í´ï¼°Ö¬ÖÊÐî»ý. Öйú¶¯ÂöÓ²»¯ÔÓÖ¾. 2014£»22£¨7£©£º669-67412. Ì·ÓñÁÖ,ÔøÓ±,ĪÖгÉ,Ò×¹â»Ô*. ¸ßÌǶÔHDLµ÷½ÚTHP-1¾ÞÊÉϸ°ûCD36ºÍ¹ýÑõ»¯ÌåÔöÖ³ÎＤ»îÐÍÊÜÌå¦Ã±í´ïµÄÓ°Ïì. Öйú¶¯ÂöÓ²»¯ÔÓÖ¾. 2014£»22£¨6£©£º553-55713. Ì·ÓñÁÖ,ÔøÓ±,ĪÖгÉ,Ò×¹â»Ô*. ¸ßÌǶÔTHP-1¾ÞÊÉϸ°ûCD36±í´ï¼°Ö¬ÖÊÐî»ýµÄÓ°ÏìÖйú¶¯ÂöÓ²»¯ÔÓÖ¾. 2014£»22£¨5£©£º438-44214. Liu xing, SuoRong, Xiong Sheng-ling, Zhang Qing-hai, Yi Guang-hui*, HDL carriers drug for targeted therapyClinChimActa415(2013):**.01£¨SCI£¬2010-2011IF£º2.388£©15. ÕÅ´óé¦, ÎéÈÙ, ³ÑÞ¾Õ, Ò×¹â»Ô*. 1-Á×ËáÇÊ°±´¼ÊÜÌåÔÚÐÄѪ¹ÜϵͳÖеÄ×÷Óü°ÆäÐźŻúÖÆ. Öйú¶¯ÂöÓ²»¯ÔÓÖ¾. 2013£»21£¨11£©£º1047-105216. Zhang QH Zu XY Cao RX Liu JH Mo ZC Zeng Y Li YB Xiong SL Liu X Liao DF Yi GH*. An involvement of SR-B1 mediated PI3K-Akt-eNOS signaling in HDL-induced cyclooxygenase 2 expression and prostacyclin production in endothelial cells. BiochemBiophys Res Commun. 2012 Mar 30420(1):17-23. Epub 2012 Feb 27.£¨SCI£¬2010-2011IF£º2.595£©17. Liu X, Xiong SL, Yi GH*. ABCA1, ABCG1, and SR-BI: Transit of HDL-associated sphingosine-1-phosphate. ClinChimActa. 2012 Feb 18413(3-4):384-90. Epub 2011 Nov 13. PMID:**[PubMed - in process] doi:10.1016/j.cca.2011.11.002£¨SCI£¬2010-2011IF£º2.388£©18. Liu X, Zhang QH, Yi GH*. Regulation of metabolism and transport of sphingosine-1-phosphate in mammalian cells. Mol Cell Biochem. 2012 Apr363(1-2):21-33. Epub 2011 Nov 24.£¨SCI£¬2010-2011IF£º2.168£©19. ÔøÓ±, ËïÓñ»Û, »ÆÑÓ½õ, Ò×¹â»Ô*. ¹ýÑõ»¯ÌåÔöÖ³ÎＤ»îÐÍÊÜÌå¦Ã¶Ô¾ÞÊÉϸ°ûÖ¬ÖÊÐî»ý¼°CD36±í´ïµÄÓ°Ïì. Öйú¶¯ÂöÓ²»¯ÔÓÖ¾, 2012,20(2): 121-124.20. ĪÖгÉ, ³ÂÐÀ, ÁúÖηå, ÔøÓ±, ÕÅÇຣ, Ò×¹â»Ô*. ciglitazone¶Ô¾ÞÊÉϸ°ûCD36±í´ï¼°µ¨¹Ì´¼Á÷ÈëµÄÓ°Ïì. ϸ°ûÓë·Ö×ÓÃâÒßѧÔÓÖ¾. 2011 27(6): 685-687ÖйúÉúÎﻯѧÓë·Ö×ÓÉúÎïѧ»áÖ¬ÖÊÓëÖ¬µ°°×öλÔÓéÀֵǼÈë¿ÚÏÂÔØίԱ»áίԱ£»ºþÄÏÊ¡²¡ÀíÉúÀíѧѧ»áÀíÊ¡¢ÐÄѪ¹Ü¼²²¡öλÔÓéÀֵǼÈë¿ÚÏÂÔØίԱ»áίԱ¡¢½ÌѧöλÔÓéÀֵǼÈë¿ÚÏÂÔØίԱ»áίԱ£»¡¶Öйú¶¯ÂöÓ²»¯ÔÓÖ¾¡·±àί£¬¡¶ÖйúÒ©ÀíѧÓ붾ÀíѧÔÓÖ¾¡·ÌØÔ¼Éó¸åÈË£¬¡¶Medicinal Research Reviews¡·¡¢¡¶Angiogenesis¡·ºÍ¡¶3Biotech¡·Éó¸åר¼Ò¡£

½ÌÓý±³¾° :
1979.09¡ª1984.07£¬±±¾©Ò½Ñ§Ôº¹«¹²ÎÀÉúöλÔÓéÀֵǼÈë¿ÚÏÂÔØ£¬»ñҽѧѧʿѧλ¡£1995.09¡ª1998.06£¬ºâÑôҽѧԺ²¡ÀíÉúÀíѧöλÔÓéÀֵǼÈë¿ÚÏÂÔØ£¬»ñҽѧ˶ʿѧλ¡£1998.09¡ª2003.06£¬ÖÐÄÏ´óѧ²¡ÀíѧÓ벡ÀíÉúÀíѧöλÔÓéÀֵǼÈë¿ÚÏÂÔØ£¬»ñҽѧ²©Ê¿Ñ§Î»¡£2006.06¡ª2008.05£¬ËÕÖÝ´óѧÁÙ´²Ò½Ñ§öλÔÓéÀֵǼÈë¿ÚÏÂÔØ£¬³öÕ¾²©Ê¿ºó