öλÔÓéÀֵǼÈë¿ÚÏÂÔØ

µ¼Ê¦ÐÕÃû£ºÐìÐÂÔÆ
ÐÔ±ð£ºÄÐ
ÈËÆøÖ¸Êý£º1228

ËùÊôԺУ£ºÄÏ»ª´óѧ
ËùÊôԺϵ£º¹«¹²ÎÀÉúѧԺ
Ö°³Æ£ºÖ÷ÈÎҽʦ
µ¼Ê¦ÀàÐÍ£º
ÕÐÉúöλÔÓéÀֵǼÈë¿ÚÏÂÔØ£º¹«¹²ÎÀÉú˶ʿ


ͨѶ·½Ê½ :
°ì¹«µç»°£º**
µç×ÓÓʼþ£ºxyxu2008@163.com
ͨѶµØÖ·£ºÉîÛÚÊÐÄÏɽÇøÁúԷ·8ºÅÉîÛÚÊм²²¡Ô¤·À¿ØÖÆÖÐÐÄ


¸öÈ˼òÊö :
2015Äê»ñÉîÛÚÊпÆѧ¼¼Êõ½ø²½½±¶þµÈ½±£¬ÏîÄ¿Ãû³Æ¡°ÈýÂÈÒÒÏ©ÖÂÑÏÖØÖ°Òµ²¡Î£º¦µÄ·¢²¡»úÖÆÓë·ÀÖμ¼ÊõÑо¿¡±£¬µÚÒ»»ñ½±Õߣ»2014Äê»ñÖйúÖ°Òµ°²È«½¡¿µÐ­»á¿Æ¼¼½±Ò»µÈ½±£¬µÚÒ»»ñ½±Õߣ»2013Äê»ñ¹ã¶«Ê¡¿Æ¼¼½ø²½½±ÈýµÈ½±¡°¼¸Ààз¢Ê³Ô´ÐÔ¼²²¡µÄ²¡ÒòÑо¿ºÍÔ¤·À¿ØÖÆ¡±£¬µÚ3»ñ½±Õߣ»2013Äê»ñÖлªÔ¤·Àҽѧ½±ÈýµÈ½±£¬µÚ3»ñ½±Õß¡£»ñµÃ¹ú¼Ò·¢Ã÷רÀû3ÏîÊÚȨ£¨ÅÅÃûµÚÒ»£©

¿ÆÑй¤×÷ :
1984Äꡪ1996Ä꣺ÔÚºþÄÏÊ¡ÀͶ¯ÎÀÉúÖ°Òµ²¡Ñо¿Ëù¹¤×÷£¬Ö÷Òª´ÓÊÂÖ°Òµ²¡ºÍ¶¾ÀíѧÑо¿£¬1995Äê½úÉý¸±Ö÷ÈÎҽʦ2000Äꡪ2006£º´ÓÃÀ¹ú»Ø¹úµ½ÉîÛÚÊм²²¡Ô¤·À¿ØÖÆÖÐÐŤ×÷£¬2001Äê½úÉýÖ÷ÈÎҽʦ£¬Ö°ÒµÎÀÉú¿ÆÖ÷ÈÎ2006ÄꡪÖÁ½ñ£ºÉîÛÚÊм²²¡Ô¤·À¿ØÖÆÖÐÐĶ¾ÀíʵÑéÊÒ¹¤×÷£¬¸±Ö÷ÈΣ¬Ë¶Ê¿µ¼Ê¦1.Xinyun Xu,Yuebin Ke, Jianhui Yuan,et al. Trichloroethylene-induced hypersensitivity dermatitis was associated with hepatic metabolic enzyme genes and immune-related genes. Toxicology Research, 2016,5(2), 633-640.2. XinyunXu, et al. Altered expression of hepatic metabolic enzyme and apoptosis-related gene transcripts in human hepatocytes treated with trichloroethylene. Human and Experimental Toxicology, 2012, 31(9) 861¨C867.3. XinyunXu, et al. Oxidative stress and inducible nitric oxide synthase expression in human hepatocytes treated with trichloroethylene. Toxicological& Environmental Chemistry. 2010, 92(4):801-811.4.Xinyun XU, Rongxing YANG, et al. Severe Hypersensitivity Dermatitis and LiverDysfunction Induced by Occupational Exposureto Trichloroethylene. Ind Health 2009, 47(2):107-112. 5.Yuebin Ke,Xinyun Xu,Shuang Wu. Protective Effects of Extracts from Fructus rhodomyrti againstOxidative DNA Damage In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity 2013, Volume 2013, 1-8. http://dx.doi.org/10.1155/2013/507407.6.Yuebin Ke, Xiaobei Duan, Feiqiu Wen, Xinyun Xu, et al. Association of melamine exposure with urinary stone and oxidative DNA damage in infants. Archives of Toxicology 2010, 84(4): 301-307.7.Desheng Wu, Jianjun Liu, Qionghui Zhao, Xinyun Xu, et al.Characterization of the disposition of melamine in female Sprague-Dawley rats using ultra-performance liquid chromatography-tandem mass spectrometry. Journal of Analytical Toxicology. 2011,35:551-557.8.ÇØåÐÔÆ£¬ÐìÐÂÔÆ£¬Ì·ÇÙ£¬µÈ.MEHP¶ÔCHOϸ°ûµòÍö»ùÒòºÍ°©»ùÒò±í´ïˮƽµÄÓ°Ïì.Ö°ÒµÓ뽡¿µ£¬2016,32(7):909-912.(ͨѶ×÷Õß)9.ÐìÐÂÔÆ, ÇØåÐÔÆ, Ì·ÇÙ,µÈ. ÁÚ±½¶þ¼×Ëá¶þ(2-ÒÒ»ù¼º)õ¥£¨DEHP£©¶Ô´óÊóغÍèºÍÂѳ²×éÖ¯¼¤ËØÏà¹Øµ°°×±í´ïµÄÓ°Ïì. °©±ä»û±äÍ»±ä2015,27(3)225-229.10.Ì·ÇÙ, ÇØåÐÔÆ,ÐìÐÂÔÆ,µÈ. DEHP¶ÔCHOϸ°ûµòÍö»ùÒòºÍ°©»ùÒò±í´ïˮƽµÄÓ°Ïì. ÏÖ´úÔ¤·Àҽѧ 2015, 42(6)1089-1092. (ͨѶ×÷Õß)11.ÎâµÂÉú£¬ÇØåÐÔÆ£¬Ì·ÇÙ£¬ÐìÐÂÔÆ. ÁÚ±½¶þ¼×Ëáõ¥À໯ºÏÎïµÄÉúÖ³¶¾ÐÔ¼°Æä»·¾³ÄÚ·ÖÃÚ¸ÉÈÅЧӦ. °©±ä»û±äÍ»±ä2015,27(4)316-322.(ͨѶ×÷Õß)12.ÁÎÈÕÑ×, ÐìÐÂÔÆ. ÈýÂÈÒÒÏ©¶Ô¸Îϸ°ûµòÍö»ùÒòºÍ¸Î´úлø»ùÒò±í´ïˮƽµÄÓ°Ïì. ʵÓÃÔ¤·Àҽѧ, 2015, 22(7):873-876.13. ÕÅʤ£¬³Â½ðÈ㣬ÐìÐÂÔÆ. ʵʩÁ¿»¯·Ö¼¶Ç°ºóµç¶ÆÆóÒµÖ÷ÒªÖ°Òµ²¡Î£º¦ÒòËØÇé¿ö·ÖÎö.Öлª¼²²¡¿ØÖÆÔÓÖ¾,2014,18(5):459-461.14.ÐìÐÂÔÆ£¬ÀîѧÓ࣬ÁõÔ·å. ÈýÂÈÒÒÏ©ÖÂϸ°ûÃâÒߺÍÌåÒºÃâÒß²ÎÓëµÄ»ìºÏÐͱä̬·´Ó¦Ñо¿. ÖлªÀͶ¯ÎÀÉúÖ°Òµ²¡ÔÓÖ¾, 2014,32(12)881-886.15.ÐìÐÂÔÆ,ë٩ÀÅ, Ô¬½¨»Ô£¬µÈ.ÈýÂÈÒÒÏ©¶ÔCYP2E1»ùÒò¸ß±í´ïϸ°ûºÍÕý³£¸Îϸ°û¶¾ÐÔ×÷ÓÃ. ÖлªÀͶ¯ÎÀÉúÖ°Òµ²¡ÔÓÖ¾, 2014,32(10)723-727.16.ÇØåÐÔÆ, Ì·ÇÙ,ÐìÐÂÔÆ,µÈ. DEHP¶Ô´óÊóغÍ財ÀíËðº¦Ó볬΢½á¹¹Ó°Ïì.ÖйúÎÀÉú¼ìÑéÔÓÖ¾2014,24(22):3228-3231. (ͨѶ×÷Õß)17.ÇØåÐÔÆ, Ì·ÇÙ, ÐìÐÂÔÆ. ÁÚ±½¶þ¼×Ëá¶þÒÒ»ù¼ºõ¥¶ÔÐÛÐÔ´óÊó¼¤ËØÏà¹Ø»ùÒò±í´ïˮƽµÄÓ°Ïì.°©±ä»û±äÍ»±ä2014,26(5)365-368.(ͨѶ×÷Õß)18.Ì·ÇÙ£¬ÇØåÐÔÆ£¬ÐìÐÂÔÆ. ÁÚ±½¶þ¼×Ëá¶þÒÒ»ù¼ºõ¥¶Ô´óÊóÂѳ²²¡ÀíË𺦺ͳ¬Î¢½á¹¹µÄÓ°Ïì.°©±ä»û±äÍ»±ä2014, 26(5)369-373. (ͨѶ×÷Õß)19.Ì·ÇÙ£¬ÇØåÐÔÆ£¬ÐìÐÂÔÆ. ÁÚ±½¶þ¼×Ëá¶þÒÒ»ù¼ºõ¥¶Ô´óÊóÂѳ²µòÍö»ùÒòºÍ°©»ùÒò±í´ïˮƽӰÏì.°©±ä»û±äÍ»±ä2014,26(5)374-381. (ͨѶ×÷Õß)20.ÐìÐÂÔÆ,ë٩ÀÅ,Ô¬½¨»Ô,µÈ. CYP3A4³ÁĬϸ°ûÖ꽨Á¢¼°Æä¶ÔÈýÂÈÒÒÏ©¶¾ÐÔµÄÓ°Ïì. ¶¾ÀíѧÔÓÖ¾, 2014,28(1):58-63. 21.ÐìÐÂÔÆ,ë٩ÀÅ. CYP2E1»ùÒò¹ý±í´ïϸ°ûÖêµÄ½¨Á¢¼°¼ø¶¨. °©±ä?»û±ä?Í»±ä 2014,26(2): 127-130. 22.ë٩ÀÅ,ÐìÐÂÔÆ,뼪Ñ×,µÈ. CYP3A4¸ß±í´ïϸ°ûÖ꽨Á¢¼°Æä¶ÔÈýÂÈÒÒÏ©¶¾ÐÔµÄÓ°Ïì. ÖйúÒ©Àí¶¾ÀíѧÔÓÖ¾, 2013,27(5):848-853. (ͨѶ×÷Õß)23.ÐìÐÂÔÆ,뼪Ñ×,ë٩ÀÅ,µÈ.ϸ°ûÉ«ËØCYP2E1»ùÒò³ÁĬ¶ÔÈýÂÈÒÒÏ©ÖÂL02¸Îϸ°û¶¾ÐÔµÄÓ°Ïì. ÖлªÀͶ¯ÎÀÉúÖ°Òµ²¡ÔÓÖ¾ 2013, 31(3)172-177.24.ë٩ÀÅ,ÐìÐÂÔÆ,뼪Ñ×,µÈ. ÈýÂÈÒÒÏ©¶ÔCYP1A2¸ß±í´ï¸Îϸ°ûÖêµòÍö»ùÒòºÍ°©»ùÒòµÄÓ°Ïì. °©±ä?»û±ä?Í»±ä. 2013, 25(1)7-12. (ͨѶ×÷Õß)25.ÐìÐÂÔÆ,ë٩ÀÅ,뼪Ñ×,µÈ. CYP1A2»ùÒò³ÁĬ¼°Æä¶ÔÈýÂÈÒÒÏ©¶¾ÐÔÓ°ÏìÑо¿. Öйúְҵҽѧ, 2013,40(4)287-291.26.ÐìÐÂÔÆ, ë٩ÀÅ. CYP1A2»ùÒòÔÚÈýÂÈÒÒÏ©¶¾ÐÔÖеÄ×÷ÓÃÑо¿. Ö°ÒµÎÀÉúÓëÓ¦¼±¾ÈÔ® 2013, 31(3):115-118.27.뼪Ñ×,ÐìÐÂÔÆ, ºÎÏþÑô,µÈ.CYP2E1»ùÒòRNA¸ÉÈÅÔØÌåµÄ¹¹½¨Óë±í´ï. °©±ä?»û±ä?Í»±ä 2012,24(4):290-294. (ͨѶ×÷Õß)28.ÐìÐÂÔÆ,ÁõÔ·å,Áõ¹úºì,µÈ.ÈýÂÈÒÒÏ©±ä̬·´Ó¦Æ¤Ñײ¡È˸δúлø»ùÒò±í´ïˮƽÑо¿. ¶¾ÀíѧÔÓÖ¾ 2012,26(2):121-124. 29.ÐìÐÂÔÆ,ÁõÔ·å,Ò×¾ê,µÈ.ÈýÂÈÒÒÏ©Ò©ÕîÑùƤÑײ¡ÈËÍâÖÜѪc-fos/c-myc/k-rasºÍp53»ùÒò±í´ïˮƽµÄÑо¿. °©±ä?»û±ä?Í»±ä 2012,24(1):56-59.30. ÐìÐÂÔÆ,ÀîѧÓà,ÁõÔ·å,µÈ. ÈýÂÈÒÒÏ©ÖÂÃôëàÊóÆ¢ÁÜ°Íϸ°ûÃâÒßÏà¹Ø»ùÒòmRNA±í´ïˮƽµÄÑо¿. ÖлªÔ¤·ÀҽѧÔÓÖ¾ 2011, 45(2):186-187.31. ÐìÐÂÔÆ/ÁõÔ·å/뼪Ñ×/Ô¬½¨»Ô£¬µÈ. ÈýÂÈÒÒÏ©¶Ô¸Îϸ°û´úлø»ùÒòÓëµòÍö»ùÒò±í´ïµÄÓ°Ïì. °©±ä?»û±ä?Í»±ä 2011,23(5):349-352.32.ÐìÐÂÔÆ,¿ÂÔ¾±ó,¶¡Àûƽ,µÈ. ÂÈ»¯ïÓ¶Ô´óÊóÉöÉÏƤϸ°ûË¿ÁÑÔ­»î»¯µ°°×¼¤Ã¸±í´ï¼°ÆäÁ×ËữµÄÓ°Ïì. ÖлªÔ¤·ÀҽѧÔÓÖ¾ 2010, 44(12)1131-1135.33.ÁõÔ·å,ÐìÐÂÔÆ,ÀîѧÓà,µÈ.ÈýÂÈÒÒÏ©¶ÔëàÊóÆ¢ºÍÍâÖÜѪÁÜ°Íϸ°ûµòÍö»ùÒò±í´ïˮƽµÄÓ°Ïì. °©±ä?»û±ä?Í»±ä£¬2010,22(5): 379-382. (ͨѶ×÷Õß)34.ÐìÐÂÔÆ,ÌÕ¹¦»ª,ÎâµÂÉú,µÈ. Èý¾ÛÇè°·ÑǼ±ÐÔ¾­¿ÚȾ¶¾´óÊóºóÉöÓë°òë××éÖ¯²¡Àíѧ¼ì²é·ÖÎö. ÖйúÔ¤·ÀҽѧÔÓÖ¾ 2010, 11(5)459-461.35.ÐìÐÂÔÆ,¶¡Àûƽ, ÀîѧÓ࣬µÈ. Èý¾ÛÇè°·¶Ô´óÊóÉö×éÖ¯Ô­°©»ùÒò±í´ïˮƽµÄÓ°Ïì. Öйú¹«¹²ÎÀÉú 2010, 26(7)829-830.36.ÐìÐÂÔÆ,ÁõÔ·å,ÀîѧÓà,µÈ. ÈýÂÈÒÒÏ©¶ÔëàÊóÐØÏÙÁÜ°Íϸ°ûµòÍö»ùÒòmRNA±í´ïµÄÓ°Ïì. ¶¾ÀíѧÔÓÖ¾ 2010, 24(5)372-37.37.Xinyun Xu, Keith J. Miller. Prevention of DOI-mediated wet dog shake by inhibitors of nitric oxide synthase. Brain Research 1998, 804:337-340.38.Xinyun Xu, Cubeddu LX, Malave A. Expression of inducible nitric oxide synthase in primary culture of rat bladder smooth muscle cells by plasma from cyclopho- sphamide-treated rats. Eur J Pharmacol 2001 , 416 (1-2):1-9.39.Xinyun Xu, Malave A.Protective effect of berberine on cyclophosphamide-induced haemorrhagic cystitis in rats. Pharmacol Toxicol 2001, 88(5): 232- 237.40 .Xinyun Xu£¬Andres Malave. p38 MAPK, but not p42/p44 MAPK mediated iNOS expression in C6 glioma cells.LifeScience 2000, 67 (26):3221-3230.41.Xinyun Xu, Keith J. Miller. Inducible nitric oxide synthase in P11 cells. Biochemical Pharmacology2000, 59: 509-516.42. Liu JD, Liu JJ, Yuan JH, Tao GH, Wu DS, Xu XY, Hu JJ, Zhuang ZX. Proteome of melamine urinary bladder stones and implication for stone formation. Toxicol Lett, 2012, 212(3) 307-314. 43. Dong S, Xiong W, Yuan J, Li J, Liu J, Xu X. MiRNA-146a regulates the maturation and differentiation of vascular smooth muscle cells by targeting NF-¦ÊB expression. Mol Med Rep. 2013, 8(2):407-412. DOI:?10.3892/mmr.2013.153844. Liu J, Xing X, Huang H, Jiang Y, He H, Xu X, Yuan JH, Zhou L, Yang L, Zhuang Z. Identification of antigenic proteins associated with trichloroethylene-induced autoimmune disease by serological proteome analysis. Toxicol Appl Pharmacol. 2009, 240(3):393-400.45. Yang JF,Ding XF,Chen L,Mat WK,Ke YB,Xu XY, Copy number variation analysis based on AluScan sequences. J Clin Bioinforma.2014 ,4(1):15. doi: 10.1186/s13336-014-0015-z.Öйú»·¾³ÓÕ±ä¼Áѧ»áÀíÊ£»Öйú»·¾³ÓÕ±ä¼Áѧ»áÖÂÍ»±äöλÔÓéÀֵǼÈë¿ÚÏÂÔØίԱ»á¸±Ö÷ÈÎίԱ£»Öйú¶¾Àíѧ»á¶¾ÀíѧʷöλÔÓéÀֵǼÈë¿ÚÏÂÔØίԱ»á¸±Ö÷ÈÎίԱ£»Öйú¶¾Àíѧ»áÃâÒ߶¾ÀíöλÔÓéÀֵǼÈë¿ÚÏÂÔØίԱ»áίԱ£»ÖлªÔ¤·Àҽѧ»á×ÔÓÉ»ùÔ¤·ÀҽѧöλÔÓéÀֵǼÈë¿ÚÏÂÔØίԱ»áίԱ£»Öйú»·¾³ÓÕ±ä¼Áѧ»áÌæ´ú¶¾ÀíѧöλÔÓéÀֵǼÈë¿ÚÏÂÔØίԱ»áίԱ£»¹ã¶«Ê¡¶¾Àíѧ»á³£ÎñÀíÊ£»¹ã¶«Ê¡»·¾³ÓÕ±ä¼Áѧ»áÀíÊ£»¹ã¶«Ê¡ÊµÑ鶯Îïѧ»áÀíÊ£»ÉîÛÚÊÐÔ¤·Àҽѧ»á³£ÎñÀíÊ£»ÉîÛÚÊÐÔ¤·Àҽѧ»áʵÑ鶯Îï¹ÜÀíöλÔÓéÀֵǼÈë¿ÚÏÂÔØίԱ»áÖ÷ÈÎίԱ£»ÉîÛÚÊÐÔ¤·Àҽѧ»á¶¾ÀíѧÆÀ¼ÛöλÔÓéÀֵǼÈë¿ÚÏÂÔØίԱ»á¸±Ö÷ÈÎίԱ£»ÖлªÀͶ¯ÎÀÉúÖ°Òµ²¡ÔÓÖ¾±àί£»Ö°ÒµÓ뽡¿µÔÓÖ¾±àί

½ÌÓý±³¾° :
1979Äꡪ1984Ä꣺±±¾©Ò½¿Æ´óѧ¹«¹²ÎÀÉúѧԺѧϰ1987Äꡪ1990Ä꣺»ªÎ÷Ò½¿Æ´óѧ¹«¹²ÎÀÉúѧԺÑо¿Éú1997Äꡪ2000Äê: ÃÀ¹úNOVA´óѧ¶¾Àíѧ²©Ê¿ºó