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3. ¹¹½¨Á˶àÖÖÖ²Îﲡԭ¾úµÄ´úлÍøÂçºÍµ°°×Ï໥×÷ÓÃÍøÂç¡¢×é×°×¢ÊÍ¡¢±È½Ï»ùÒò×é·ÖÎö¼°³õ²½ÏµÍ³ÉúÎïѧ·ÖÎö¡£Õë¶ÔÒѲâÐòÖ²ÎïÖ²¡Ï¸¾ú×¢ÊÍÐÅÏ¢ÖдæÔÚµÄÎÊÌ⣬¶ÔËüÃǽøÐÐÁËÖØÐÂ×¢ÊÍ£¬ÎªÑо¿ÕßÌṩÁ˸üΪ¾«È·µÄ×¢ÊÍÐÅÏ¢£¬½øÒ»²½¶Ô²¿·ÖÖ²Îﲡԭ¾úµÄÖØÐÂ×¢ÊÍÐÅÏ¢½øÐÐÁËʵÑéÑéÖ¤¡£Õë¶ÔËÞÖ÷·¶Î§¹ã¡¢Î£º¦´ó¡¢È±·¦×¨ÓÃɱ¾ú¼ÁµÄºúÂܲ·Èí¸¯¹û½º¸Ë¾ú£¬¿ÎÌâ×é²ÉÓÃͬԴ»ùÒòÓ³ÉäµÄ·½·¨£¬½áºÏ»ùÒò×éÊý¾Ý¡¢ÒÑÓÐ×¢Êͼ°ÖØÐÂ×¢ÊÍÐÅÏ¢¡¢ÊµÑéÊý¾ÝÒÔ¼°ÎÄÏ×¼ìË÷£¬¹¹½¨Á˺úÂܲ·Èí¸¯¹û½º¸Ë¾úºúÂܲ·ÑÇÖÖPC1¾úÖêµÄÈ«»ùÒò×é´úлÍøÂçÄ£ÐÍ¡£¸ÃÄ£ÐÍ»ù±¾º­¸ÇÁËϸ°û±ØÐèµÄ´úл;¾¶¡£½øÒ»²½¶Ô´úлÍøÂçÖеĶ¾Á¦Òò×Ó´úлÇé¿ö½øÐзÖÎö£¬É¸Ñ¡Á˱ØÐè»ùÒò¼°Ç±ÔÚµÄɱ¾ú¼Á°Ð±ê¡£´ËÍ⻹Ԥ²âÁËÄ£Ð͵ĺϳÉÖÂËÀ»ùÒò¶Ô£¬ÎªÑ°ÕÒ¶à°Ð±ê×éºÏɱ¾ú¼Áµì¶¨ÁË»ù´¡£¨FEBS Lett. , 2015, 589: 285-94£©¡£

½üЩÄê·¢±íµÄ´ú±íÐÔÂÛÎÄ£º

1.Sun J, Liu H, Liu J, Cheng S, Peng Y, Zhang Q, Yan J, Liu HJ*,Chen LL*.CRISPR-Local: a local single-guide RNA (sgRNA) design tool for non-reference plant genomes.Bioinformatics, bty970,https://doi.org/10.1093/bioinformatics/bty970

2.Song JM, Lei Y, Shu CC, Ding Y, Xing F, Liu H, Wang J, Xie W, Zhang J,Chen LL*. Rice Information GateWay: a comprehensive boinformatics platform for indica rice genomes.Mol Plant, 2018, 11(3):505-507.

3.Liu H, Ding Y, Zhou Y, Jin W, Xie K*,Chen LL*.CRISPR-P 2.0: an improved CRISPR-Cas9 tool for genome editing in plants.Mol Plant, 2017, 10(3):530-532.

4.Zhang J#,Chen LL#, Sun S, et al. Building two indica rice reference genomes with PacBio long-read and Illumina paired-end sequencing data.Sci Data, 2016, 3:160076.#Co-firstauthors.

5.Zhang J#,Chen LL#, Xing F#, et al. Extensive sequence divergence between the reference genomes of two elite indica rice varieties Zhenshan 97 and Minghui 63.ProcNatl Acad Sci U S A, 2016, 113(35): E5163-71.#Co-firstauthors.

6.Ding Y, Li H,Chen LL*, Xie K*. Recent advances in genome editing using CRISPR/Cas9.Front Plant Sci., 2016, 7:703.

7.Guo J, Zhang H, Wang C, Chang JW,Chen LL*. Construction and analysis of a genome-scale metabolic network forBacillus licheniformisWX-02.Res Microbiol., 2016, 167(4): 282-9.

8.Guo J, Cheng G, Gou XY, Xing F, Li S, Han YC, Wang L, Song JM, Shu CC, Chen SW*,Chen LL*. Comprehensive transcriptome and improved genome annotation ofBacillus licheniformisWX-02.FEBS Lett., 2015, 589(18): 2372-81.

9.Wang C, Deng ZL, Xie ZM, Chu XY, Chang JW, Kong DX, Li BJ, Zhang HY,Chen LL*. Construction of a genome-scale metabolic network of the plant pathogenPectobacterium carotovorumprovides new strategies for bactericide discovery.FEBS Lett., 2015, 589(3): 285-94.

10.Chen D, Fu LY, Zhang Z, Li G, Zhang H, Jiang L, Harrison AP, Shanahan HP, Klukas C, Zhang HY, Ruan Y*,Chen LL*, Chen M*. Dissecting the chromatin interactome of microRNA genes.Nucleic Acids Res.,2014, 42(5): 3028-43.

11.Ding YD, Chang JW, Guo J, Chen D, Li S, Xu Q, Deng XX, Cheng YJ,Chen LL*. Prediction and functional analysis of the sweet orange protein-protein interaction network.BMC Plant Biol.,2014, 14(1): 213.

12.Lei Y, Lu L, Liu HY, Li S, Xing F,Chen LL*. CRISPR-P: A Web Tool for Synthetic Single-Guide RNA Design of CRISPR-System in Plants.Mol Plant,2014, 7(9): 1494-1496.

13.Guo FB, Lin Y,Chen LL*. Recognition of protein-coding genes based on Z-curve algorithms.Current Genomics, 2014, 15:95-103.

14.Xu Q#,Chen LL#, Ruan X#, et al. The draft genome of sweet orange (Citrus sinensis).Nature Genetics, 2013, 45: 59-66.#Co-firstauthors.

15.Jiao WB, Huang D, Xing F, HuY, Deng XX, Xu Q*,Chen LL*. Genome-wide characterization and expression analysis of genetic variants in sweet orange.Plant J., 2013, 75: 954-964.

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