The Juno actress graces the cover of the US publication in an exquisite floor-sweeping backless turquoise gown for the November issue honouring fantastic females.
The 35-year-old star - who has a 22-month old daughter, Violet, with husband Ben Affleck - has been recognised as a shining example of how to juggle a successful career and a happy family life with style and elegance.
The former Alias star will be honoured at a glitzy event at New York's Lincoln Centre on November 5.
Nobel-prize winning novelist Toni Morrison and golfer Lorena Ochoa are among 12 other women who will also be celebrated at the glamorous event.
Oscar-nominated actress Abigail Breslin, 11, will be honoured at the ceremony after being named as the first ever Girl of the Year.
In June, Victoria Beckham was named UK Glamour magazine's Woman of the Year.
The Spice Girl, who also won Entrepreneur of the Year, attended the London event dressed in a corset and pair of frilly knickers.
Somaly Mam - a "modern-day saint" who devoted her life to rescuing girls from sex slavery - was named the US Glamour magazine's Woman of the Year in 2006.
