öλÔÓéÀֵǼÈë¿ÚÏÂÔØ

»ªÖÐÅ©Òµ´óѧÐÅϢѧԺÉúÎïÐÅϢϵÑо¿Éúµ¼Ê¦Âí±ò¹ã½éÉÜÈçÏ£º

Âí±ò¹ã£¬ÄУ¬²©Ê¿£¬»ªÖÐÅ©Òµ´óѧÐÅϢѧԺ, ½ÌÊÚ ²©Ê¿Éúµ¼Ê¦

µç»°£º027-87280877

ÓÊÏ䣺mbg@mail.hzau.edu.cn

¹¤×÷µ¥Î»

»ªÖÐÅ©Òµ´óѧÐÅϢѧԺ

Ñо¿·½Ïò

ÉúÎïÎïÀíѧ£»¼ÆËãÉúÎïѧ£»ÏµÍ³ÓëºÏ³ÉÉúÎïѧ

½ÌÓý¾­Àú

2004.9-2007.6, ËÕÖÝ´óѧ, ¸ß·Ö×Ó»¯Ñ§ÓëÎïÀí£¨»¯Ñ§ÉúÎïѧ·½Ïò£©, ²©Ê¿

2001.9-2004.6, Ìì½ò´óѧ, ÉúÎïÎïÀíѧ, ˶ʿ

1997.9-2001.7, ºÓ±±¹¤Òµ´óѧ, Ó¦ÓÃÎïÀíѧ, ±¾¿Æ

Ö÷ÒªÖ°Àú

2016.12ÖÁ½ñ, »ªÖÐÅ©Òµ´óѧÐÅϢѧԺ, ½ÌÊÚ ²©Ê¿Éúµ¼Ê¦

2014.7-2016.12, »ªÖÐÅ©Òµ´óѧÐÅϢѧԺ, ¸±½ÌÊÚ

2009.11-2014.7, »ªÖÐÅ©Òµ´óѧÉúÃü¿Æѧ¼¼ÊõѧԺ, ¸±½ÌÊÚ

2007.11-2009.11, Bergen Center for Computational Sciences, Norway£¨Å²Íþ£©, ²©Ê¿ºó

ѧÊõ¼æÖ°£º

NatureÆìϹú¼Ê¿¯ÎïScientific Reports±àί

iGEM¹ú¼ÊÒÅ´«¹¤³Ì»úÆ÷Éè¼Æ¾ºÈü2013ÑÇÖÞÈüÇøÆÀί

µÚ°Ë½ì¹ú¼ÊÉúÎïÐÅÏ¢ÑÐÌÖ»á(IBW2010-Î人)×éί»á³ÌÐòίԱ

¿ÆÑгɹû

½ü¼¸ÄêÀ´Ö÷ÒªÔÚ¼ÆËãÉúÎïѧÁìÓò´ÓÊ»ùÒò×é·ÖÎö¡¢µ°°×ÖÊÕÛµþ¼°µ°°×ÖÊÏ໥×÷Óá¢Î¢ÉúÎïÈÈÊÊÓ¦µÄ·Ö×Ó»úÀíµÈ·½ÏòµÄÑо¿¹¤×÷£¬ÔÚNucleic Acid Res., Structure, PLoS Comput Biol., Sci. Rep., J. Mol. Biol.,Proteins, Genome Biol., BMC Genomics, PLoS One, FEBS J., FEBS Lett., Gene, Biochem. Biophys. Res. Commun.µÈ¹ú¼ÊÖØÒªÆÚ¿¯·¢±íSCIÂÛÎÄ20¶àƪ£¬ÆäÖУ¬¹ØÓÚµ°°×ÖÊÕÛµþÀàÐÍÔ¤²âµÄJMBÂÛÎÄÈëÑ¡Faculty of 1000 Biology¡£±¾ÈËÔøÊÜÑûµ£ÈιúÄÚÍâÖØÒªÆÚ¿¯Éó¸åÈË£¬ÀýÈ磺Journal of Chemical Information and Modeling, The Open Structural Biology Journal, Journal of Molecular Biology, Journal of Theoretical Biology, Molecular BioSystems, Gene, Genomics, Journal of Biomolecular Structure & Dynamics¡¢ÉúÎïÎïÀíѧ±¨µÈ¡£

·¢±íÂÛÎÄ£º£¨Éϱê1±íʾ²¢ÁеÚÒ»×÷Õߣ¬ÐǺÅ* ±íʾͨѶ×÷Õߣ©

1. Yi Yang, Xiao-Pan Hu,Bin-Guang Ma*, Construction and simulation of the Bradyrhizobium diazoefficiens USDA110 metabolic network: a comparison between free-living and symbiotic states. Mol. BioSyst., 2017, (First published online 31 Jan 2017). http://pubs.rsc.org/en/content/articlelanding/2017/mb/c6mb00553e

2. Hong-Rui Xu, Jun-Feng Cheng, Xiao-Pan Hu, Ying-Ying Chu,Bin-Guang Ma*, Are protein hubs faster folders? Exploration based on Escherichia coli proteome. Amino Acids 2016, 48(12): 2747–2753. http://link.springer.com/article/10.1007/s00726-016-2309-x

3.Âí±ò¹ã£¬µ°°×ÕÛµþÔ¤²â£¬¿Æѧͨ±¨ 61(24), 2670-2680 (2016); doi: 10.1360/N972016-00658£» £¨Ô¼¸å×ÛÊö£¬Science125¸ö¿ÆѧǰÑØÎÊÌâϵÁнâ¶Á£¬µÚ58ÎÊ£ºCan we predict how proteins will fold?£©http://engine.scichina.com/doi/10.1360/N972016-00658

4. Yi-Ming He,Bin-Guang Ma*, Abundance and Temperature Dependency of Protein-Protein Interaction Revealed by Interface Structure Analysis and Stability Evolution. Sci Rep. 2016 May 25; 6:26737. doi:10.1038/srep26737.

5. Xiao-Pan Hu, Yi Yang,Bin-Guang Ma*, Amino Acid Flux from Metabolic Network Benefits Protein Translation: the Role of Resource Availability. Sci Rep. 2015 Jun 9; 5:11113. doi: 10.1038/srep11113.

6. Ting Xie1, Liang-Yu Fu1, Qing-Yong Yang1, Heng Xiong1, Hong-Rui Xu,Bin-Guang Ma*, Hong-Yu Zhang*, Spatial features for Escherichia coli genome organization, BMC Genomics. 2015 Feb 5;16:37. doi: 10.1186/s12864-015-1258-1.

7. Heng Xiong, Yi Yang, Xiao-Pan Hu, Yi-Ming He,Bin-Guang Ma*, Sequence determinants of prokaryotic gene expression level under heat stress. Gene 2014, 551: 92-102.

8. Shanming Wang, Baohai Hao, Jiarui Li, Huilin Gu, Jieli Peng, Fuli Xie, Xinyin Zhao, Christian Frech, Nansheng Chen*,Binguang Ma*, Youguo Li*, Whole-genome sequencing of Mesorhizobium huakuii 7653R provides molecular insights into host specificity and symbiosis island dynamics. BMC Genomics 2014, 15:440 (6 June 2014)

9. Jieli Peng, Baohai Hao, Liu Liu, Shanming Wang,Binguang Ma, Yi Yang, Fuli Xie, Youguo Li RNA-Seq and Micros Analyses Reveal Global Differential Transcriptomes of Mesorhizobium huakuii 7653R between Bacteroids and Free-Living Cells. PLoS ONE (2014) 9(4): e93626. doi:10.1371/journal.pone.0093626.

10. Alexander Goncearenco,Bin-Guang Ma, and Igor N. Berezovsky, Molecular mechanisms of adaptation emerging from the physics and evolution of nucleic acids and proteins Nucl. Acids Res. (2014) 42 (5): 2879-2892.

11. Qiang Zhu1, Tao Qin1, Ying-Ying Jiang1, Cong Ji1, De-Xin Kong1,Bin-Guang Ma1, Hong-Yu Zhang* Chemical basis of metabolic network organization. PLoS Comput Biol. 2011 (10): e1002214.

12. Liang-Yu Fu, Guang-Zhong Wang,Bin-Guang Ma, Hong-Yu Zhang* Exploring the common molecular basis for the universal DNA mutation bias: revival of Löwdin mutation model. Biochem Biophys Res Commun. (2011) 409: 367-371.

13.Bin-Guang Ma*, Hong-Yu Zhang* Stoichiometry and Preferential Interaction: Two Components of the Principle for Protein Structure Organization. Journal of Biomolecular Structure & Dynamics. (2011) 28: 619-20; discussion 669-674.

14.Bin-Guang Ma, Igor N. Berezovsky* The MBLOSUM: a server for deriving mutation targets and position-specific substitution rates. Journal of Biomolecular Structure & Dynamics (2010), 28, 415-419.

15. Bin-Guang Ma1, Alexander Goncearenco1, Igor N. Berezovsky* Thermophilic adaptation of protein complexes inferred from proteomic homology modeling. Structure (2010) 18, 819-828.

16.Bin-Guang Ma*, Ling-Ling Chen, Hong-Yu Zhang. FDserver: A web service for protein folding research. NaturePrecedings (2008)

17.Bin-Guang Ma* Building Block and Building Rule: Dual Descriptor Method for Biological Sequence Analysis. Nature Precedings (2008) .

18. Ji Wang,Bin-Guang Ma*, Hong-Yu Zhang, Ling-Ling Chen, Shi-Cui Zhang*. How does gene expression level contribute to thermophilic adaptation of prokaryotes? An exploration based on predictors. Gene (2008) 421, 32-36.

19.Bin-Guang Ma1, Lei Chen1, Hong-Fang Ji, Zhong-Hua Chen, Fu-Rong Yang, Ling Wang, Ge Qu, Ying-Ying Jiang, Cong Ji, Hong-Yu Zhang*. Characters of very ancient proteins. Biochemical & Biophysical Research Communications (2008) 366, 607-611.

20.Bin-Guang Ma*, Ling-Ling Chen, Hong-Yu Zhang*. What determines protein folding type? An investigation of intrinsic structural properties and its implications for understanding folding mechanisms. Journal of Molecular Biology (2007) 370, 439-448. ¸ÃÂÛÎÄÈëÑ¡Faculty of 1000 Biology

21. Yan Zhou1,Bin-Guang Ma1, Hong-Yu Zhang*. Human oncogene tissue-specific expression level significantly correlates with sequence compositional features. FEBS Letters (2007) 581, 4361-4365.

22. Ke Xu andBin-Guang Ma*. Comparative analysis of predicted gene expression among deep-sea genomes. Gene (2007) 397, 136-142.

23.Bin-Guang Ma*. How to describe genes: enlightenment from the quaternary number system. BioSystems (2007) 90, 20-27.

24.Bin-Guang Ma*, Jian-Xiu Guo, Hong-Yu Zhang*. Direct correlation between proteins' folding rates and their amino acid compositions: an ab initio folding rate prediction. Proteins: Structure, Function, and Bioinformatics (2006) 65, 362-372.

25.Bin-Guang Ma, Qin Song, Hong-Yu Zhang*. CvP-bias as an index to predict the life style of last common ancestor. Journal of Biomolecular Structure & Dynamics, 23 (2006) 555-558.

26.Bin-Guang Ma, Ling-Ling Chen*. The Most Deviated Condon Position in AT-rich genomes: a function related analysis. Journal of Biomolecular Structure & Dynamics (2005), 23, 143-149.

27. Guang-Zhong Wang1,Bin-Guang Ma1, Yan Yang, Hong-Yu Zhang*. Unexpected amino acid composition of modern Reptilia and its implications in molecular mechanisms of dinosaur extinction. Biochemical & Biophysical Research Communications (2005) 333, 1047-1049.

28. Ling-Ling Chen,Bin-Guang Ma, Na Gao. Reannotation of hypothetical ORFs in plant pathogen Erwinia carotovora subsp. atroseptica SCRI1043. FEBS Journal (2008) 275, 198-206.

29. Hong-Fang Ji, De-Xin Kong, Liang Shen, Ling-Ling Chen,Bin-Guang Ma, Hong-Yu Zhang*. Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery. Genome Biology (2007) 8:R176.

30. Hao Wu,Bin-Guang Ma, Ji-Tao Zhao and Hong-Yu Zhang*. How similar are amino acid mutations in human genetic diseases and evolution. Biochemical & Biophysical Research Communications (2007) 362, 233-237.

31. Hao Wu, Yan Yang, Sheng-Juan Jiang, Ling-Ling Chen, Hai-Xia Gao, Qing-Shan Fu, Feng Li,Bin-Guang Ma, Hong-Yu Zhang. DCCP and DICP: construction and analyses of databases for copper- and iron-chelating proteins. Genomics Proteomics Bioinformatics (2005) 3, 52-57.

32. Ðìºêî£,Âí±ò¹ã* µ°°×ÖÊÕÛµþËÙÂʾö¶¨ÒòËØÓëÔ¤²â·½·¨µÄÑо¿½øÕ¹ ÉúÎïÎïÀíѧ±¨£¨2013£©Vol. 29 (3): 192-202.

33. ¹ù½¨Ðã,Âí±ò¹ã,ÕźìÓê* µ°°×ÖÊÕÛµþËÙÂÊÔ¤²âÑо¿½øÕ¹ ÉúÎïÎïÀíѧ±¨ 2006 Vol. 22 (2): 89-95.

34.Âí±ò¹ãÔ­ºË»ùÒòʶ±ðÖеÄÒ»ÖÖ¸ºÑù±¾Éú³ÉËã·¨ ¡¶Ìì½òÀí¹¤Ñ§ÔºÑ§±¨¡· 2004Äê01ÆÚ

רÖøÕ½Ú£º

Âí±ò¹ã¡¢ºÂ±£º£¡¢ºúÏþÅÊ¡¢ÍõË«Òú£¬Öйú΢ÉúÎï»ùÒò×éÑо¿£¨Õ½ړԭºË΢ÉúÎïµÄζÈÊÊÓ¦»úÖÆ£º×éѧÊӽǔ pp: 400-413£©£¬¿Æѧ³ö°æÉ磬2012.

ÀîÓѹú¡¢ÍõÉÆÃ÷¡¢Åí½ÜÀö¡¢Âí±ò¹ã£¬Öйú΢ÉúÎï»ùÒò×éÑо¿£¨Õ½ړ¸ùÁö¾ú¹¦ÄÜ»ùÒò×éѧÑо¿¸ÅÊö”pp: 166-180£©£¬¿Æѧ³ö°æÉ磬2012.

ѧÊõ»áÒ飨ÂÛÎÄ/ÕªÒª/Õ¹±¨/±¨¸æ£©£º

The 16th International Conference on Systems Biology (ICSB 2015), November 23-26, 2015, Biopolis, Singapore, Abstract&Poster: "Amino Acid Flux from Metabolic Network Benefits Protein Translation: the Role of Resource Availability".

Genomics Frontiers Symposium, July 16-19, 2015, Beijing, Abstract: "Spatial Organization of E. coli Transcriptional Regulatory Network".

The Twelfth International Bioinformatics Workshop (IBW2015), July 9-10, 2015, Harbin, China, Abstract: "Metabolic Channeling: Integrated Analysis of Human Cancer Protein-protein Interaction and Metabolic Networks".

The 2nd International SystemsX.ch Conference on Systems Biology, Oct, 2014, Lausanne, Switzerland, Abstract&Poster: "Spatial Features for Escherichia coli Genome Organization".

The 15th International Systems Biology Conference, Sep, 2014, Melbourne, Australia, Abstract&Poster: "Construction and Simulation of Bradyrhizobium japonicum USDA110 Metabolic Network: New Insights for Symbiotic Nitrogen Fixation Metabolism".

µÚÈý½ìÖйú΢ÉúÎï»ùÒò×éѧÊõÑÐÌֻᣬ2010Äê11Ô£¬ÉîÛÚ£¬ÕªÒª/±¨¸æ£º"Thermophilic Adaptation of Prokaryotic Genomes".

Öйú¿ÆѧԺÖÇÄܼÆËãÓëÉúÎïÐÅϢѧѧÊõÑÐÌֻᣬ2006Äê11Ô£¬ºÏ·Ê£¬ÂÛÎÄ/±¨¸æ£º“µ°°×ÖÊÕÛµþËÙÂʼÆË㔡£

¿ÆÑÐÏîÄ¿£º

ϸ¾úÈýά»ùÒò×éÈÈÊÊÓ¦µ÷¿Ø»úÀíµÄϵͳÉúÎïѧÑо¿£¬¹ú¼Ò×ÔÈ»¿Æѧ»ù½ð£¨31570844£©£¬Ö÷³Ö£¬2016.1-2019.12

Ô­ºË»ùÒò±í´ïˮƽÈÈÊÊÓ¦µ÷¿Ø»úÀíµÄϵͳÉúÎïѧÑо¿£¬¹ú¼Ò×ÔÈ»¿Æѧ»ù½ð£¨31100602£©£¬Ö÷³Ö£¬2012.1-2014.12

µ°°×¸´ºÏÎïµÄÈÈÎȶ¨ÐÔÓëÆäÑÇ»ù±í´ïˮƽºÍÕÛµþËÙÂʹØϵµÄÑо¿£¬½ÌÓý²¿Áôѧ»Ø¹úÈËÔ±¿ÆÑÐÆô¶¯»ù½ð£¨122064£©£¬Ö÷³Ö£¬2012.1-2014.12

ÉúÎïÓë·ÇÉúÎïÒò×ÓÓÕ·¢¹ûʵ²ÉºóË¥ÀϵÄÉúÎïѧ»ù´¡£¬973ÏîÄ¿£¨2013CB127103£©£¬Ñ§Êõ¹Ç¸É£¬²ÎÓ룬2013.1-2017.9

»ùÓÚÕñµ´Æ÷µÄÐéʵ»ìºÏÉúÎï»Ø·µÄ¹¹½¨£¬Ð£×ÔÖ÷±êÖ¾ÐԳɹûÅàÓýÏîÄ¿£¨2662016PY094£©£¬Ö÷³Ö£¬2016.1-2018.12

΢ÉúÎï´úл;¾¶Á÷ƽºâ·ÖÎöƽ̨½¨Éè¼°Ó¦Óã¬Ð£×ÔÖ÷´´Ð»ù½ð½»²æÏîÄ¿£¨2013JC009£©£¬Ö÷³Ö£¬2013.1-2014.12

Ô­ºË»ùÒòÈÈÊÊÓ¦±í´ïˮƽԤ²â£¬Ð£×ÔÖ÷´´Ð»ù½ðÅàÓýÏîÄ¿£¨2011PY070£©£¬Ö÷³Ö£¬2011.5-2012.12

¸ùÁö¾úµ°°×Ï໥×÷ÓÃ×éµÄ½¨Ä£ÓëÑéÖ¤£¬Ð£×ÔÖ÷´´Ð»ù½ðÇàÄê½ÌʦÏîÄ¿£¨2010QC016£©£¬Ö÷³Ö£¬2011.1-2012.12

ºìÇú¾úÖÐPKS»ùÒòµÄ±È½Ï»ùÒò×éѧ·ÖÎö¼°ÖØÒª»ùÒò¹¦ÄÜÑéÖ¤£¬Ð£×ÔÖ÷´´Ð»ù½ð½»²æÏîÄ¿£¨2011JC009£©£¬¹²Í¬ÉêÇëÈË£¬2011.5-2012.12

´ËÍâ²ÎÓ룺

»ùÓÚ×éѧµÄÐÂÒ©·¢ÏÖ¼¼Êõ£¬ºþ±±Ê¡×ÔÈ»¿Æѧ»ù½ð´´ÐÂȺÌ壨2013CFA016£©£¬2014-2016

ÎIJýÓã¼Ù¶¨»ùÒò¹¦ÄÜÔ¤²âÓëʵÑéÑéÖ¤£¬863ÏîÄ¿£¨2008AA09Z411£©

ºúÂܲ·Èí¸¯Å·ÎÄÊϾú¹¦ÄÜ»ùÒò·ÖÎö¼°Ò©Îï°Ðµã³õɸ£¬¹ú¼Ò×ÔÈ»¿Æѧ»ù½ðÏîÄ¿£¨30600119£©

ϸ°ûÐÍëò¡¶¾µ°°×´íÎóÕÛµþ»úÀíµÄÀíÂÛÑо¿£¬¹ú¼Ò×ÔÈ»¿Æѧ»ù½ðÏîÄ¿£¨30570383£©

½Ì¸ÄÏîÄ¿£º

ϵͳÉúÎïѧ£¬Ñо¿Éú½ÌÓý´´Ð¹¤³ÌÏîÄ¿(2010KC06)£¬Ö÷³Ö£¬2010-2012.

ºÏ³ÉÉúÎïѧ´´ÐÂÐÍʵÑ飬´´ÐÂÐÔʵÑé¿Î³ÌÏîÄ¿£¬Ö÷³Ö£¬2016.

½ÌѧÂÛÎÄ£º

ÌïÁù¡¢ÂÞÐñ¶«¡¢ÕźìÓê¡¢Âí±ò¹ã*¡¢½ð°²½­*£¬iGEM¾º½Ì½áºÏÌáÉýѧÉú¿ÆÑд´ÐÂÄÜÁ¦¼°×ÛºÏËØÖÊ£¬¸ßУÉúÎïѧ½ÌѧÑо¿£¨µç×Ӱ棩2016Äê 6 Ô£¬6 (2): 57-62.

Âí±ò¹ã£¬Ç³Ì¸Ê¦ÕßÖ®“·¶”µÄÈý¸ö²ã´Î£¬£¨Àî³ç¹â ½­çñÖ÷±à£º¡¶´´Ð·½·¨ ׿¶û²»Èº£º»ªÖÐÅ©Òµ´óѧ“´´Ð·½·¨ ÌáÉýÖÊÁ¿”½ÌÓý˼Ïë´óÌÖÂ۳ɹûÎļ¯¡·£¬Ò³: 326-328. ¸ßµÈ½ÌÓý³ö°æÉ磬±±¾©£¬2015.12¡££©

±¸×¢

Ö¸µ¼´óѧÉú¾ºÈü£º

iGEM-2015, Ö¸µ¼Ñ§Éú¸°ÃÀ¹ú²¨Ê¿¶Ù²ÎÈü£¬»ñµÃ½ð½±£¬²¢»ñµÃBest Information Processing ProjectÌáÃû¡£

iGEM-2014, ´ø¶Ó¸°ÃÀ¹ú²¨Ê¿¶Ù²ÎÈü£¬»ñµÃ½ð½±¡£

iGEM-2013, ´ø¶Ó¸°Ïã¸Û²ÎÈü£¬»ñµÃ½ð½±¡£

2007Ä꣬ɽ¶«Àí¹¤´óѧ£¬Ö¸µ¼±¾¿ÆÉúÔÚ“ÌôÕ½±­”È«¹ú´óѧÉú¿ÎÍâѧÊõ¿Æ¼¼×÷Æ·¾ºÈüÖлñµÃ¶þµÈ½±¡£

2005Ä꣬ɽ¶«Àí¹¤´óѧ£¬Ð­ÖúÖ¸µ¼±¾¿ÆÉúÔÚ“ÌôÕ½±­”È«¹ú´óѧÉú¿ÎÍâѧÊõ¿Æ¼¼×÷Æ·¾ºÈüÖлñµÃÒ»µÈ½±¡£

Ö÷½²¿Î³Ì£º

Bioinformatics (ÁôѧÉú¿Î³Ì£¬È«Ó¢ÓïÊÚ¿Î)£¬2011ÄêÇ»ªÖÐÅ©Òµ´óѧ

ϵͳÉúÎïѧ £¨Ñо¿Éú¿Î³Ì£©£¬×Ô2010ÄêÇ￪ʼ£¬»ªÖÐÅ©Òµ´óѧ, ¿Î³ÌÍøÕ¾£ºhttp://ibi.hzau.edu.cn/bgma/sysbio/teaPlan.html

½ø»¯ÓëÉú̬ £¨±¾¿ÆÉú¿Î³Ì£©£¬×Ô2011Äê´º¿ªÊ¼£¬»ªÖÐÅ©Òµ´óѧ

PythonÓïÑÔ±à³Ì£¨±¾¿ÆÉú¿Î³Ì£©£¬×Ô2013ÄêÇ￪ʼ£¬»ªÖÐÅ©Òµ´óѧ

ϵͳÓëºÏ³ÉÉúÎïѧ£¨±¾¿ÆÉú¿Î³Ì£©£¬×Ô2014´º¿ªÊ¼£¬»ªÖÐÅ©Òµ´óѧ